Multicharge beta-cyclodextrin supramolecular assembly for ATP capture and drug release
Water-soluble seven hexylimidazolium modified amphiphilic cyclodextrin (AMCD) selectively combined with ATP to form a stable 1 : 1 inclusion complex
Category: Drug delivery
Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2
Drug combination strategies of repurposed drugs offer a number of advantages to monotherapies including the potential to achieve greater efficacy,
Thiolated cyclodextrins: Mucoadhesive and permeation enhancing excipients for ocular drug delivery
Thiolated β-cyclodextrin (β-CD) has the potential to enhance mucoadhesive and permeation enhancing properties on ocular mucosa. Thiolated β-CD was synthesized via replacement
An interesting hypothesis: CD‐sACE2 inclusion compounds to treat COVID‐19
Angiotensin‐converting enzyme 2 (ACE2) has been identified as the main receptors for SARS‐CoV and SARS‐CoV‐2. Soluble ACE2 (sACE2) can bind
FDA Issues Emergency Use Authorization for Third COVID-19 Vaccine
As we reported on CDN blog FDA approval for Janssen vaccine containing HPBCD was expected in late February. The Janssen
Improving Bioavailability & Solubility
Drug Development & delivery published on the virtual 2020 Global Drug Bioavailability Enhancement Summit, which this past December showcased novel
Heptakis(6-amino-6-deoxy)-beta-cyclodextrin stabilizes the synthetic anticoagulant fondaparinux
The intermolecular interactions between the cationic per-6-amino-b-CD with the highly anionic heparin analogue anticoagulant fondaparinux were studied at two different
KAZIA LICENSES CANTRIXIL TO OASMIA
Kazia Therapeutics Limited, an Australian oncology-focused biotechnology company, announced that it has entered into an exclusive worldwide license agreement with
Aerogels in drug delivery. Review
Aerogels are the lightest processed solid materials on Earth and with the largest empty volume fraction in their structure. Composition
New approach in ocular drug delivery: cyclodextrin-containing mucoadhesive eye drop formulations
In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects. The toxicity and