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Category: Supramolecular systems

August 16, 2023 Drug delivery / Pharma applications / Supramolecular systems

Rationally designed multifunctional nanoparticles as GSH-responsive anticancer drug delivery systems based on host-guest polymers derived from dextran and β-cyclodextrin

Tumor proliferation and metastasis rely on energy provided by mitochondria. The hexokinase inhibitor lonidamine (LND) could suppress the activities in

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July 7, 2023 Supramolecular systems

Special issue on “The Self-Assembly and Design of Polyfunctional Nanosystems 3.0”

This Special Issue will be devoted to (i) fundamental aspects of self-assembly of amphiphilic compounds including surfactants, polymers, macrocycles, and

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June 20, 2023 Drug delivery / Pharma applications / Supramolecular systems

Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (IV) prodrug delivery and enhanced colorectal cancer therapy

Oxaliplatin (Oxa) is the first-line chemotherapeutic drug for the treatment of colorectal cancer (CRC). However, long-term Oxa chemotherapy can induce

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May 25, 2023 Supramolecular systems

Exploring Isomerism in Isolated Cyclodextrin Oligomers through Trapped Ion Mobility Mass Spectrometry

Cyclodextrin (CD) macrocycles are used to create a wide range of supramolecular architectures which are also of interest in applications

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March 31, 2023 Drug delivery / Pharma applications / Supramolecular systems

Nitric Oxide-Releasing Topological Supramolecular Nanocarriers with sliding CD units against MRSA

Polymeric systems that provide cationic charges or biocide-release therapeutics are used to treat the bacteria-infected wound. However, most antibacterial polymers

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October 14, 2022 Drug delivery / Pharma applications / Supramolecular systems

Stimuli-responsive cyclodextrin-based supramolecular assemblies as drug carriers

In this review with 169 references, the recent advances in stimuli-responsive supramolecular assemblies based on the host–guest chemistry of CDs

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October 7, 2022 CD as API / Pharma applications / Supramolecular systems

Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis

A promising therapy for atherosclerosis treatment was designed by targeting LXR receptor (LXR) on atherosclerotic macrophage, where LXR activation could

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September 27, 2022 CD derivatives / Drug delivery / Pharma applications / Supramolecular systems

Advances in the development of cyclodextrin-based nanogels/microgels for biomedical applications: Drug delivery and beyond

Nanogels/microgels are swollen cross-linked polymer networks with tunable physicochemical properties and are commonly employed for the effective delivery of hydrophilic

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September 21, 2022 Pharma applications / Supramolecular systems

Lipid-based artificial motors – liposome movements via cholesterol extraction

In this work, it is demonstrated that liposome active motion takes advantage of mainly a pair of intrinsic material properties

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September 20, 2022 CD derivatives / Drug delivery / Life sciences / Supramolecular systems

New US patent application on ternary CD/small guest molecule/protein interactions

Cyclolab Ltd filed a patent application (US20220282001) on cyclodextrin containing physical mixtures and inclusion complexes that show improved protein stabilizing

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  • Geographical variation of gut microflora shows diversity in catabolizing alpha-cyclodextrin

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