Cyclodextrin complexation of selected tyrosine kinase inhibitors
The comprehensive physicochemical characterization and cyclodextrin complexation of four tyrosine kinase inhibitors — erlotinib, gefitinib, vandetanib, and lapatinib — were
Tag: HPBCD
CD in prevention of dengue-induced lethality
Annexin A1 (AnxA1) was identified as an endogenous regulator of inflammation in dengue. Treatment with the AnxA1 peptidomimetic, Ac2-26, improved
A Bubble-Driven Drug Delivery System Enhances Oral Absorption and Antipyretic Efficacy of Poorly Water-Soluble Andrographolide
The Bubble-Driven Drug Delivery System (BDDS, a new name for effervescent formulations) was optimized through the screening of effervescent formulations
Improving Drug Bioavailability with Cyclodextrin Complexes: An integrative meta-modeling approach
This study integrates molecular modeling and meta-analysis to evaluate the pharmacokinetic performance and molecular stability of various cyclodextrin-drug systems. A
HPβCD’s Promise in Treating Ischemic Stroke
Ischemic stroke is a leading cause of mortality and long-term disability worldwide, with limited pharmacological interventions available. 2-hydroxypropyl-β-cyclodextrin (HPβCD), a
Evaluation of the Potential Therapeutic Effects of HPβCD and SBEβCD in a Mouse Model of Acute Ulcerative Colitis
A Nanjing, China based research group designed a tailored investigation [1] based on a surprising previous study [2]. In they
HPBCD accesses acute and subacute infarcts in a mouse model of ischemic stroke
Ischemic stroke is a leading cause of mortality and long-term disability worldwide, with limited pharmacological interventions available. Researchers in Arizona
Toxic effects and cellular uptake of functional polyrotaxanes. The little we have learned and the many unknowns still waiting to be discovered.
Cyclodextrins are commonly used as excipients in modern drug delivery, but they also have a less common role as active
Beren Therapeutics’Adrabetadex Received FDA Acceptance for infantile-onset Niemann Pick Disease
Beren Therapeutics Announced FDA Acceptance of its New Drug Application for Adrabetadex in Infantile-Onset Niemann-Pick Disease Type C. Beren Therapeutics
The mechanism of ototoxicity studied by using HPBCD
The cochlea is the sensory organ responsible for hearing. Central to its sensory functions is the organ of Corti, a