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Tag: HPBCD

June 10, 2022 Drug delivery / Pharma applications

Biophysical Studies and In Vitro Effects on Tumor Cell Lines of Cannabidiol and Its Cyclodextrin Inclusion Complexes

Phytocannabinoids possess anticancer properties, as established in vitro and in vivo. However, they are characterized by high lipophilicity. To improve

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June 1, 2022 CD as API / Pharma applications

Brain uptake and distribution patterns of 2-hydroxypropyl-ß-cyclodextrin after intrathecal and intranasal administration

2-hydroxypropyl-ß-cyclodextrin (kleptose) is used for the treatment of Niemann–Pick disease. Kleptose crosses the blood–brain barrier poorly, in part because of

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May 27, 2022 Drug delivery / Pharma applications

Insulin Complexation with Cyclodextrins—A Molecular Modeling Approach

Around 5% of the population of the world is affected with the disease called diabetes mellitus. The main medication of

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May 26, 2022 CD derivatives / Drug delivery / Pharma applications

Life cycle of Tecovirimat authorized to treat human monkeypox infection in EU has been extended by reformulation with HPBCD by the originator Siga Technologies.

Tecovirimat SIGA (marketed under the trade name TPOXX® in USA) is an oral medicine to treat smallpox, monkeypox and cowpox,

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May 16, 2022 Cosmetics and toilettry / Non-pharma applications

Have you ever washed your hands with HPBCD-containing soap? Check it out!

Dettol is a brand of cleaning supplies, disinfectant and antiseptic, introduced in 1932. The manufacturer is owned by the British

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April 19, 2022 CD derivatives

Two ways for manufacturing CD fibres

In this work [1], (2-Hydroxypropyl)- β-cyclodextrin) fibres were successfully produced with water, as the “green” solvent with pressurised gyration and electrospinning,

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April 18, 2022 Drug delivery / Pharma applications

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

Intranasal administration is a promising route for brain drug delivery. However, it can be difficult to formulate drugs that have

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March 17, 2022 Environmental / Non-pharma applications

HPBCD as detoxification agent for disinfection byproducts

The health effects of disinfection byproducts (DBPs) in drinking water drew great attention recently. Herein, by using in vitro (fluorescence quenching, UV

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February 23, 2022 CD as API / Pharma applications

HPBCD for Treatment of Parkinson Disease

The recent work of Jarazo et al. demonstrates that HP-β-CD ameliorates the dopaminergic neuronal loss phenotype, confirming the therapeutic potential

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February 21, 2022 Drug delivery / Pharma applications

Direct cyclodextrin-based powder extrusion 3D printing for one-step production of the BCS class II model drug Niclosamide

Direct extrusion of hydroxypropyl beta-cyclodextrin (HP-β-CD)-based powder blends using the most innovative 3D printing technology, Direct Powder Extrusion (DPE), is

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