HPBCD for the treatment of irreversible white matter injury
White matter repair relies on microglial clearance of cholesterol-rich myelin debris. Microglia have been reported to predominantly depend on de
Category: Life sciences
Environment-Sensitive Fluorophores Report on Structural Organization of Biological Membranes at Various Depths
Molecular-order-related membrane biophysical properties contribute to the functional modulation of transmembrane proteins, and therefore, their changes due to a modified
Obituary for Prof. Dr.-Ing. Wolfram Saenger
Prof. Dr.-Ing. Wolfram Saenger passed away on 16 February 2026. He was a German biochemist and protein scientist renowned for
Betadex sulfobutylether sodium — a key enabler for potent neurotherapeutics
In the search for better therapies for neurodegenerative diseases like Parkinson’s, researchers are increasingly looking beyond classical drugs to the
Studies on Sleep-Deprived Animals Reveal HPBCD’s Role in Restoring Normal Neuronal Function
A study published in Proceedings of the National Academy of Sciences (https://www.pnas.org/doi/10.1073/pnas.2523438123) suggests that lack of sleep harms the fatty
Harnessing Organoid Platforms for Nanoparticle Drug Development
Cancer nanomedicine holds transformative potential, but its clinical translation remains hindered by the lack of preclinical models that accurately mimic
Patent applications related to synthesis of heptakis(2,6-di-O-alkyl)-beta-cyclodextrin by CycloLab
45 years ago, Szejtli et al. reported on the synthesis of heptakis(2,6-di-O-methyl)-beta-cyclodextrin using dimethyl sulfate as alkylating agent in a
Hydrogel containing oxidized beta-cyclodextrin for in-vivo release of a medication: a sheep model
Cyclodextrins are seldom used in sustained-release formulations, as they are more commonly associated with rapid drug delivery. However, cyclodextrin complexes
Serum-free media
Albumin is a crucial component of serum-free media, playing a significant role in ex vivo cell culture as a lipid carrier
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
The association between cellular senescence and ABCA1 expression in human postmortem brain samples was studied using transcriptomic, histological, and biochemical