Cyclodextrins may help a therapeutic agent en route to the brain
From curcuminoid solubilization to potential boron neutron capture therapy for Alzheimer’s disease What if a cyclodextrin could help take a
Category: Life sciences
Cyclodextrin Helps Analyzing 3D Histology of Archived Human Tissues
What if decades-old human tissue archives could be transformed from thin, two-dimensional histological sections into detailed three-dimensional maps of cells,
HPBCD for the treatment of irreversible white matter injury
White matter repair relies on microglial clearance of cholesterol-rich myelin debris. Microglia have been reported to predominantly depend on de
Environment-Sensitive Fluorophores Report on Structural Organization of Biological Membranes at Various Depths
Molecular-order-related membrane biophysical properties contribute to the functional modulation of transmembrane proteins, and therefore, their changes due to a modified
Obituary for Prof. Dr.-Ing. Wolfram Saenger
Prof. Dr.-Ing. Wolfram Saenger passed away on 16 February 2026. He was a German biochemist and protein scientist renowned for
Betadex sulfobutylether sodium — a key enabler for potent neurotherapeutics
In the search for better therapies for neurodegenerative diseases like Parkinson’s, researchers are increasingly looking beyond classical drugs to the
Studies on Sleep-Deprived Animals Reveal HPBCD’s Role in Restoring Normal Neuronal Function
A study published in Proceedings of the National Academy of Sciences (https://www.pnas.org/doi/10.1073/pnas.2523438123) suggests that lack of sleep harms the fatty
Harnessing Organoid Platforms for Nanoparticle Drug Development
Cancer nanomedicine holds transformative potential, but its clinical translation remains hindered by the lack of preclinical models that accurately mimic
Patent applications related to synthesis of heptakis(2,6-di-O-alkyl)-beta-cyclodextrin by CycloLab
45 years ago, Szejtli et al. reported on the synthesis of heptakis(2,6-di-O-methyl)-beta-cyclodextrin using dimethyl sulfate as alkylating agent in a
Hydrogel containing oxidized beta-cyclodextrin for in-vivo release of a medication: a sheep model
Cyclodextrins are seldom used in sustained-release formulations, as they are more commonly associated with rapid drug delivery. However, cyclodextrin complexes