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Tag: Captisol

May 17, 2022 Drug delivery / Pharma applications

Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-beta-cyclodextrin

In terms of solubilization effect, it was found that phase solubility of RDV increased significantly from intrinsic 1.7 mmol/L at

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April 29, 2022 Drug delivery / Pharma applications

FDA Approves First COVID-19 Treatment for Young Children

The press release was published on the U.S. Food and Drug Administration website: On Apr. 26, 2022, the U.S. Food

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April 13, 2022 Drug delivery / Pharma applications

Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine Formulation for Subcutaneous Injection

Subcutaneous (SC) ketamine has been found to be effective in pain management, though reports of injection site irritation and sterile

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April 11, 2022 Drug delivery / Pharma applications

Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir

The aim of this report is to review the literature and shed light on the uncertainties surrounding the use of

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January 25, 2022 Drug delivery / Pharma applications

FDA Approves Veklury® (Remdesivir) for the Treatment of Non-Hospitalized Patients at High Risk for COVID-19 Disease Progression

— Approval Based on Phase 3 Data Showing Veklury Significantly Reduced Risk of Hospitalization By 87% Compared with Placebo —

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January 18, 2022 Drug delivery / Pharma applications

Voriconazole–Cyclodextrin Supramolecular Ternary Complex-Loaded Ocular Films

Prof. Lewis’ group used the multicomponent complex formation of CDs with hydroxy acids to improve the pharmacokinetic of voriconazole. Fungal

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November 25, 2021 Drug delivery / Pharma applications

Remdesivir interactions with sulfobutylether-b-cyclodextrins: A case study using selected substitution patterns

A structural and thermodynamic analysis for the interaction between SBECD and neutral or protonated remdesivir has been performed using multiple

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September 21, 2021 Drug delivery / Pharma applications

Marinus Announces FDA Acceptance for Filing and Priority Review of NDA for SBECD-enabled Ganaxolone in CDKL5 Deficiency Disorder

Marinus Pharmaceuticals, Inc. , a pharmaceutical company dedicated to the development of innovative therapeutics to treat seizure disorders, announced that

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August 12, 2021 Drug delivery / Pharma applications

Marinus Pharmaceuticals and Orion Corporation agree on Commercialization of SBECD-enabled Ganaxolone

Marinus Pharmaceuticals, Inc. (Nasdaq: MRNS), a pharmaceutical company dedicated to the development of innovative therapeutics to treat seizure disorders, announced that

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February 15, 2021 Drug delivery / Pharma applications

Reviews on remdesivir in Covid-19 treatment

Remdesivir (GS-5734; Gilead Sciences Inc., US) is an investigational nucleoside analog that acts as a competitive inhibitor of viral RNAdependent

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