Posted by Researchers from Brazil 🇧🇷 developed a HPβCD-based system to improve the stability, safety, and antioxidant activity of ferulic acid for topical applications. Compared with free ferulic acid, the CD-containing system demonstrated 20-fold greater cellular safety and approximately 8x greater antioxidant efficiency, while also providing a more controlled release profile. When incorporated into sunscreen formulations, it increased sun protection even when UV filters were reduced by 50%, highlighting the potential of CD-based systems to improve the performance of antioxidant and sunscreen formulations.
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In vitro release profiles of FA (Ferulic acid) from formulations F1, F2, F7, and F8.
F1: formulation with FA and sunscreens (5% butyl methoxydibenzoylmethane and 10% ethylhexyl methoxycinnamate); F2: formulation with CF (Cicloferulic®) and sunscreens (5% butyl methoxydibenzoylmethane and 10% ethylhexyl methoxycinnamate); F7: formulation with FA and no sunscreens; F8: formulation with CF and no sunscreens.
Cicloferulic® was prepared by mixig FA and HPβ-CD in a 1:1 molar ratio, with the subsequent addition of PVP K30 polymer (w/w). After homogenization of the powders, an ethanol: water solution was added until a paste formed, which was then dried.
Freire, J.V.A.; Duarte, F.Í.C.; da Costa Dantas, L.M.; Santana, J.L.A.; Augusto, P.P.; de Assis, C.F.; de Sousa Junior, F.C.; Gomes, A.P.B.; Nogueira, F.H.A.; Lopes, P.S.; et al. Multifunctional System with Ferulic Acid: Increased Safety, Antioxidant Activity, and Efficacy of Sunscreen Formulations. Antioxidants 2026, 15, 885. https://doi.org/10.3390/antiox15070885
Featured image: https://www.unc.edu/discover/boost-your-sun-protection-with-these-tips/