HPaCD against Alzheimer Disease
HP-beta-cyclodextrin (HPbCD) is currently in clinical trials against Niemann-Pick Disease Type C (NPC) and Alzheimer’s Disease (AD) and these trials
Category: CD as API
Novel Case Study with Sugammadex in Pregnant Women
The use of sugammadex (SGM) after caesarean section is nowadays common practice, but there haven’t been reported any case studies
Ultrasound-Responsive Cyclodextrin Delivery as Therapy for Atherosclerosis
Atherosclerosis is a major cause of mortality and morbidity worldwide. Left undiagnosed and untreated, atherosclerotic plaques can rupture and cause
Cyclo Therapeutics to Present at the 2022 NPC Patient and Family Conference Hosted by the Australian NPC Disease Foundation
Presentation by Professor Caroline Hastings, MD, Chair of the Phase 3 Trappsol® Cyclo™ Program Steering Committee and the Global Principal Investigator
CIDALTEX® ANTIVIRAL MASKS DURING THE COVID-19 PANDEMIC
Prof. bernard Martel (University of Lille, France) showed how the new cyclodextrin-based mask was developed from the in-lab optimization to
CD-enabled, reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery
Nanoparticle-based therapeutics represent potential strategies for treating atherosclerosis; however, the complex plaque microenvironment poses a barrier for nanoparticles to target
Efficacy and safety of sugammadex for neuromuscular blockade reversal in pediatric patients: an updated meta-analysis of randomized controlled trials with trial sequential analysis
Background: A recent survey revealed that extensive off-label use of sugammadex in pediatric anesthesia deserved particular attention. The present study
Brain uptake and distribution patterns of 2-hydroxypropyl-ß-cyclodextrin after intrathecal and intranasal administration
2-hydroxypropyl-ß-cyclodextrin (kleptose) is used for the treatment of Niemann–Pick disease. Kleptose crosses the blood–brain barrier poorly, in part because of
Cothreading of Unmodified and Monoazidated β-Mixed cyclodextrins in polyrotaxanes for Niemann Pick disease
To establish a method for the orthogonal chemical functionalization of β-cyclodextrin (β-CD)-based polyrotaxane (PRX), unmodified and monoazidated β-CDs (N3-β-CDs) were
Implementation of water-soluble cyclodextrin-based polymers in biomedical applications: how far are we?
Cyclodextrin-based polymers can be prepared starting from the naturally occurring monomers following green and low-cost procedures. They can be selectively