Evaluation of the Potential Therapeutic Effects of HPβCD and SBEβCD in a Mouse Model of Acute Ulcerative Colitis
A Nanjing, China based research group designed a tailored investigation [1] based on a surprising previous study [2]. In they
Category: CD as API
HPBCD accesses acute and subacute infarcts in a mouse model of ischemic stroke
Ischemic stroke is a leading cause of mortality and long-term disability worldwide, with limited pharmacological interventions available. Researchers in Arizona
HPαCD Therapy: A Breakthrough for Krabbe Disease Treatment
Several North-American Universities worked together to find hydroxzpropyl-alpha-cyclodextrin(HPaCD) for the treatment of Krabbe disease. The deficiency of β-galactosylceramidase causes a
Toxic effects and cellular uptake of functional polyrotaxanes. The little we have learned and the many unknowns still waiting to be discovered.
Cyclodextrins are commonly used as excipients in modern drug delivery, but they also have a less common role as active
Beren Therapeutics’Adrabetadex Received FDA Acceptance for infantile-onset Niemann Pick Disease
Beren Therapeutics Announced FDA Acceptance of its New Drug Application for Adrabetadex in Infantile-Onset Niemann-Pick Disease Type C. Beren Therapeutics
The mechanism of ototoxicity studied by using HPBCD
The cochlea is the sensory organ responsible for hearing. Central to its sensory functions is the organ of Corti, a
Enhancing the Water Solubility and Efficacy of Anticancer Drugs Using Hydroxypropyl-β-Cyclodextrin
Previous studies have demonstrated that the solubility and biocompatibility of poorly water-soluble anti-cancer agents can be improved by complexation with
CDs for Regulating Cholesterol Homeostasis in Atherosclerosis
The progression of atherosclerosis (AS) is strongly linked to lipid crystals accumulation caused by cholesterol metabolism disorders and the worsening
Studies on Sleep-Deprived Animals Reveal HPBCD’s Role in Restoring Normal Neuronal Function
A study published in Proceedings of the National Academy of Sciences (https://www.pnas.org/doi/10.1073/pnas.2523438123) suggests that lack of sleep harms the fatty insulation that
A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice
A β-CDP (CycloLab) was used for the experiments. The purity of the β-CDP was >95 %. The β-CDP contained <1 % of