Posted by Researchers at Case Western Reserve University incorporated γ-cyclodextrin oligomers into native collagen gels during fibril formation and studied loading/release of the antibiotic Doxycycline. The cyclodextrin-containing gels dramatically improved performance: they increased the releasable amount of doxycycline by 220% while slowing release roughly fivefold. Mathematical modeling showed that this effect came specifically from affinity-based interactions between doxycycline and the cyclodextrin oligomers rather than from the collagen matrix itself. The authors specifically discuss applications for chronic peri-implantitis in dental implants, where sustained local antibiotic delivery could reduce dosing frequency and systemic side effects.
Trout E, Palomo L, von Recum HA, Eppell SJ. Doxycycline release from cyclodextrin oligomer-containing collagen gels. J Control Release. 2026 May 5;395:114955. https://doi.org/10.1016/j.jconrel.2026.114955.