Posted by This study fabricated a β/γ-CD-MOF composite via β-CD and γ-CD hybridization, incorporating the hydrophobic anti-inflammatory agent atorvastatin, followed by surface hydrophobic modification using stearic acid. The resulting hybrid material integrates the anti-phagocytic bioactivity of β-CD with the structural stability of γ-CD. Dopamine-mediated immobilization was employed to coat titanium surfaces with the composite. In vitro and in vivo experimental evaluations confirmed the coating’s exceptional stability, biocompatibility, anti-thrombotic potential, and anti-inflammatory activity. By concurrently suppressing macrophage lipid uptake (cholesterol and oxidized low-density lipoprotein) and attenuating inflammatory cytokine expression, the coating synergistically retards atherosclerotic progression. Collectively, this stabilized coating presents a novel approach for achieving the long-term stability of CD-MOFs and facilitating the surface modification of vascular stents.
Jinquan Huang, Xiaowa Gao, Jiayan Luo, Jiwei Huang, Wenzhai Cao, Junying Chen (2026) Cyclodextrin metal-organic framework engineered titanium surface: Targeted modulation of foam cell lipid homeostasis and inflammatory resolution. Colloids and Surfaces B: Biointerfaces 262, 115550,. https://doi.org/10.1016/j.colsurfb.2026.115550.