Mannose-modified methyl-β-cyclodextrin suppresses tumor growth
Methylated β-cyclodextrin (MeβCD) can extract cholesterol from lipid rafts and induce apoptosis in cancer cells by inhibiting activation of the
Tag: Cholesterol
Can CDs be utilized in/for Christmas turkey?
There many ways for applying CDs for the preparation of the traditional roasted turkey for Christmas. The method of spraying
Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?
In this review, based on 250 references, the general chemical principles of direct cyclodextrin–protein interactions are summarized and highlighted, through
Australian company pioneering Cavadextrin for regression of atherosclerosis
Newsmaker, the Australian Press Release Distribution Service has published the news on “An Australian pioneering a medical breakthrough treatment that
Inclusion Solves Insolubility ―Translational Research Cycle from Bedside to Bench and Bench to Bedside for Drug Development Targeting Niemann-Pick Disease Type C
Cyclodextrins (CDs) are used not only as pharmaceutical excipients but also as active pharmaceutical ingredients. CDs can act as artificial
Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis
A promising therapy for atherosclerosis treatment was designed by targeting LXR receptor (LXR) on atherosclerotic macrophage, where LXR activation could
Monosubstituted Maltosyl Cyclodextrins for the Potential Treatment of NPC
Niemann-Pick type C is a sever lysosomal storage disease, commonly refereed as ‘children’s Alzheimer’. There is no cure for it
Lipid-based artificial motors – liposome movements via cholesterol extraction
In this work, it is demonstrated that liposome active motion takes advantage of mainly a pair of intrinsic material properties
The Effect of Cyclodextrins in Cholesterol and Ganglioside Depletion in Rat Brain Synaptosomes
In this recently published article, the effect of four cyclodextrin derivatives on cholesterol and ganglioside depletion was investigated: two alpha
HPaCD against Alzheimer Disease
HP-beta-cyclodextrin (HPbCD) is currently in clinical trials against Niemann-Pick Disease Type C (NPC) and Alzheimer’s Disease (AD) and these trials