Disruption of Lipid Sorting and Endosomal Transport in Cyclodextrin-mediated Cytotoxicity
The effects of native and modified CDs in human renal proximal tubule cells was studied using complementary imaging, flow cytometry,
Tag: Cholesterol
HPBCD for the treatment of irreversible white matter injury
White matter repair relies on microglial clearance of cholesterol-rich myelin debris. Microglia have been reported to predominantly depend on de
Environment-Sensitive Fluorophores Report on Structural Organization of Biological Membranes at Various Depths
Molecular-order-related membrane biophysical properties contribute to the functional modulation of transmembrane proteins, and therefore, their changes due to a modified
Nano-Enabled Toxicity of Pharmaceutical Excipients
Nanotechnology has brought revolutionary advances in the pharmaceutical field. Among drug delivery systems, nanocarriers, which enhance the solubility, stability and
Cyclarity Unveils First-Ever Clinical Data Demonstrating Excretion of Oxidized Cholesterol, at American Heart Association Vascular Discovery Scientific Sessions
Cyclarity Therapeutics, Inc., a clinical stage biopharmaceutical company engineering cyclodextrin molecules into simple, scalable, and affordable therapies that bind and
HPBCD against acute and subacute infarcts in a mouse model of ischemic stroke
HPβCD has also been investigated as an active pharmaceutical ingredient (API) for the prospective treatment of ischemic stroke. We previously
HPβCD’s Promise in Treating Ischemic Stroke
Ischemic stroke is a leading cause of mortality and long-term disability worldwide, with limited pharmacological interventions available. 2-hydroxypropyl-β-cyclodextrin (HPβCD), a
CDs for Regulating Cholesterol Homeostasis in Atherosclerosis
The progression of atherosclerosis (AS) is strongly linked to lipid crystals accumulation caused by cholesterol metabolism disorders and the worsening
Studies on Sleep-Deprived Animals Reveal HPBCD’s Role in Restoring Normal Neuronal Function
A study published in Proceedings of the National Academy of Sciences (https://www.pnas.org/doi/10.1073/pnas.2523438123) suggests that lack of sleep harms the fatty insulation that
Neuroprotective effects of statins and cyclodextrins: review and potential role in dementia treatment
Dementia is a progressive and irreversible deterioration in cognition that has a significant impact on the person’s activities of daily