Cyclo Therapeutics Inc. Commences Commercial-Scale Manufacturing for Trappsol® Cyclo™
On July 27, the Cyclo Therapeutics, a clinical stage biotechnology firm dedicated to developing life-changing medicines through science and innovation
Tag: Cholesterol
Recovery, reusability and stability studies of beta cyclodextrin used for cholesterol removal from shrimp lipid
Beta cyclodextrin (β-CD) was used for cholesterol removal from shrimp lipid using ethyl acetate and water as solvents. The cholesterol
Recent reviews on cyclodextrins against SARS-CoV-2
Recent reviews emphasized the role of membrane lipids in the infectivity mechanism of SARS-COV-2. Cholesterol-rich parts of cell membranes serve
Effect of dimethyl-β-cyclodextrin on the interaction between Helicobacter pylori and steroidal compounds
The 2,6-di-O-methyl-β-cyclodextrin (dMβCD) is an amphiphilic annular compound consisting of seven dimethylglucose molecules. This compound is well known as a
Why deliver a statin in form of inclusion complex with hydrophilic cyclodextrin?
In this work, the effects of simvastatin (SIM), 2-hydroxypropyl)-β-cyclodextrin (HPβCD) and their complex (SIM: HPβCD) on the structure and properties
Targeting Lipid Rafts as a Strategy Against Coronavirus
Lipid rafts are functional membrane microdomains containing sphingolipids, including gangliosides, and cholesterol. These regions are characterized by highly ordered and
Why HPGCD is better for NPC treatment compared to HPBCD?
Niemann-Pick disease type C (NPC) is a lysosomal storage disorder with disrupted intracellular cholesterol trafficking. HP-β-CD is a cholesterol solubilizer
A polypeptide, Plitidepsin has potent preclinical efficacy against SARS-CoV-2
The science reported that the drug plitidepsin (aplidin), which has limited clinical approval, possesses antiviral activity (IC90 = 0.88 nM) 27.5-fold
Cholesterol chelator, HPβCD for renal diseases
There is increasing evidence that accumulation of intracellular lipids in the kidney contributes to the pathogenesis and progression of kidney
Treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin
Niemann-Pick Disease Type C (NPC) is a severe neurovisceral disorder that is pathophysiologically characterized by intracellular transport abnormalities leading to