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Tag: Cholesterol

January 28, 2021 Pharma applications

A polypeptide, Plitidepsin has potent preclinical efficacy against SARS-CoV-2

The science reported that the drug plitidepsin (aplidin), which has limited clinical approval, possesses antiviral activity (IC90 = 0.88 nM) 27.5-fold

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November 12, 2020 CD as API / Pharma applications

Cholesterol chelator, HPβCD for renal diseases

There is increasing evidence that accumulation of intracellular lipids in the kidney contributes to the pathogenesis and progression of kidney

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November 2, 2020 CD as API / Pharma applications

Treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin

Niemann-Pick Disease Type C (NPC) is a severe neurovisceral disorder that is pathophysiologically characterized by intracellular transport abnormalities leading to

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September 30, 2020 Drug delivery / Pharma applications

CD-related papers in Scientific Reports

Scientific reports (Nature) has published 10 cyclodextrin-related papers in the last 3 months. Here is a selection: Parvez, S., Yadagiri,

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September 28, 2020 CD as API / Drug delivery / Pharma applications

Use of cyclodextrin or its complexes as a potential treatment against the 2019 novel coronavirus

Coronavirus 2 is a member of a virus family with lipid envelope that fuses with host cell through endocytosis, internalizing

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September 21, 2020 CD as API / Pharma applications

Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic Targets.

The plasma membrane microdomain lipid rafts have been found by researchers to be involved in the replication cycle of numerous

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September 18, 2020 CD as API

Cyclodextrin-impregnated masks to prevent the transmission of coronavirus

CycloLab’s submission to InnoCentive Challenge 9934291 – New Technologies to Prevent the Transmission of Coronavirus led to a favorable evaluation.

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September 7, 2020 CD as API / Pharma applications

Potential COVID-19 therapeutics from a rare disease: utilization of lipid dysregulation to combat viral infectivity

Strategic drug repurposing in combination with rapid testing of established molecular targets could provide a pause in disease progression and

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August 12, 2020 CD as API / Drug delivery / Gene delivery / Pharma applications

The Lord of the NanoRings: cyclodextrins and the battle against SARSCoV-2

Making a comparison between CDs and the unique Ring of the legendary novel of The Lord of the Rings, J.

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July 21, 2020 CD derivatives / Drug delivery / Pharma applications

Ototoxicity of cyclodextrin derivatives

There are two possible mechanisms behind the ototoxicity of 2-hydroxypropyl-β-cyclodextrin (HPBCD) treatment. One is : the possible interaction of HPBCD

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