Update: FDA approves HPBCD-enabled tecovirimat against pox virus
As reported earlier Siga Technologies filed a patent application in the USA describing cyclodextrin solubilized tecovirimat (ST-246). Tecovirimat has low
Category: CD derivatives
Life cycle of Tecovirimat authorized to treat human monkeypox infection in EU has been extended by reformulation with HPBCD by the originator Siga Technologies.
Tecovirimat SIGA (marketed under the trade name TPOXX® in USA) is an oral medicine to treat smallpox, monkeypox and cowpox,
pH-Responsive templates modulate the dynamic enzymatic synthesis of cyclodextrins
Product selection in the dynamic enzymatic synthesis of cyclodextrins can be controlled by changing the pH. Using cyclodextrin glucanotransferase to
Implementation of water-soluble cyclodextrin-based polymers in biomedical applications: how far are we?
Cyclodextrin-based polymers can be prepared starting from the naturally occurring monomers following green and low-cost procedures. They can be selectively
Superdimer guanidino-γ-cyclodextrin
Octakis-6-guadinidino-γ-cyclodextrin (gguan) hydrochloride in the presence of phosphates crystallises from aqueous solution in the unprecedented form of a superdimer (dimer-within-a-dimer).
Dramatically Increased Binding Constant of Water-Soluble Cyclodextrin Hyperbranched Polymers
The polymerization of cyclodextrin (CD) with epichlorohydrin (ECH) dramatically increases the binding constant of CD to vanillin, from 55 to
Two ways for manufacturing CD fibres
In this work [1], (2-Hydroxypropyl)- β-cyclodextrin) fibres were successfully produced with water, as the “green” solvent with pressurised gyration and electrospinning,
Cyclodextrin-Oligocaprolactone Derivatives-Synthesis and Advanced Structural Characterization by MALDI Mass Spectrometry
The β-cyclodextrin derivatization with short oligoester chains, through convenient synthesis methods, leads to highly water-soluble and biodegradable compounds. Cyclodextrins have
Sulfated BCD templated aggregation of a molecular rotor
The recently discovered molecular rotor and supravital dye, Basic Orange-21 (BO21), has shown improved differential counting of leukocytes through metachromasia
Antidote-like effect of SBECD of plant neurotoxin veratridine on neuro-2a cell viability
A research team consisting of scientists located in Spain and Denmark have successfully proven that the formation of inclusion complexes