Enhancing Remdesivir Delivery: PJL Micelles vs SBECD Formulations
Remdesivir (REM), a nucleoside analogue that has been approved for SARS-CoV-2 treatment, is poorly soluble in water and is currently
Tag: Covid-19
Drug Repurposing as an Effective Drug Discovery Strategy
Drug repurposing, or repositioning, has emerged as a pivotal strategy in pharmaceutical research, offering a promising approach to uncover new
Hydroxypropyl-Beta-Cyclodextrin (HPBCD) inhibits SARS-CoV-2 replication by modulating intracellular lipid dynamics
A multi-year scientific collaboration between Brasilian and American scientists from Federal University at Rio de Janeiro, Brazil, Laboratory of Immunoregulation,
The revival of cyclodextrins as active pharmaceutical ingredients
Discovered in 1891, cyclodextrins, derived from starchy food, have found many applications in the cosmetic, agriculture, food and pharmaceutical industries
Modified release and permeation of umifenovir with SBE-β-CD and polymer: Impact of biorelevant gastrointestinal fluids
In this study, solubility, dissolution and permeation processes of poor soluble antiviral anti-SARS-CoV-2 umifenovir (UMF) were improved with sulfobutylether-β-cyclodextrin (SBE-β-CD)
Pulmonary Vasodilating Effects of a New Drug Formulation Containing a NO Donor Metabolite (SIN-1A) stabilized by CD
Sin1A is an unstable NO releasing metabolite of Molsidomine. Molsidomine is a prodrug that undergoes first-pass metabolism in the liver,
Veklury is the first approved antiviral agent now for extended pediatric use and for those patients who are suffering in all stages of renal disease
Veklury, a SARS-CoV-2 nucleotide analog RNA polymerase inhibitor, was approved by FDA for the treatment COVID-19 in adults and pediatric
Dual function of sulfobutylether-betadex in antiviral Veklury®: a remdesivir solubilizer and an effector
A recent publication written by a team of University of Debrecen reported that the excipient, sulfobutylether-betadex (SBECD), in Veklury® (remdesivir
Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections
The emergence and mutation of pathogenic viruses have been occurring at an unprecedented rate in recent decades. The coronavirus disease
Complexes of lycorine and its hydrochloride
Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species, such as the cultivated bush lily (Clivia miniata), surprise