Nano-Enabled Toxicity of Pharmaceutical Excipients
Nanotechnology has brought revolutionary advances in the pharmaceutical field. Among drug delivery systems, nanocarriers, which enhance the solubility, stability and
Tag: Niemann Pick Disease
A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice
A β-CDP (CycloLab) was used for the experiments. The purity of the β-CDP was >95 %. The β-CDP contained <1 % of
Cyclodextrins as Active Therapeutic Agents: Beyond Their Role as Excipients
Cyclodextrins (CDs) have traditionally been recognized as excipients that enhance solubility and stability of drugs. However, growing evidence shows that
α-CD Derivatives: Low Efficacy and Ototoxicity in NPC Models
HP-β-CD is currently under clinical investigation for treating Niemann-Pick disease type C (NPC), but its ototoxicity remains problematic. It was
The revival of cyclodextrins as active pharmaceutical ingredients
Discovered in 1891, cyclodextrins, derived from starchy food, have found many applications in the cosmetic, agriculture, food and pharmaceutical industries
The revival of cyclodextrins as active pharmaceutical ingredients
Cyclodextrins have long been known as host molecules, a special feature that has led to their widespread use in a
Long term effect of intrathecal HPBCD in patients with NP disease Type C
Based on long.term intrathecal HPBCD (IT-HPBCD) treatment of 5 patients with age of 1.4-20 years the following results were observed:
The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann–Pick Disease: A Comprehensive Review
This paper is recommended for those who want to learn more on the various types of Niemann Pick diseases. Niemann–Pick
The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann–Pick Disease: A Comprehensive Review
Niemann–Pick Disease (NPD) is a rare autosomal recessive disease belonging to lysosomal storage disorders. Three types of NPD have been
Cyclodextrins as therapeutic drugs for treating lipid metabolism disorders
This study sought to systematically compare the efficacy and mechanism of cyclodextrins as drug interventions in lipid metabolism diseases, potentially