Amongst all the strategies that can be useful in the development of parenteral formulations, the formation of water-soluble host-guest inclusion complexes with cyclodextrins (CDs) has proven to be one of the most advantageous. CDs are multifunctional pharmaceutical excipients able to form water-soluble host-guest inclusion complexes with a wide variety of molecules, particularly drugs, and thus improve their apparent water-solubility, chemical stability, and bioavailability, to make them suitable for parenteral administration. Besides, CDs can be employed as building blocks of more complex injectable drug delivery systems with enhanced characteristics, such as nanoparticles and supramolecular hydrogels, that has been found particularly beneficial for the delivery of anticancer drugs. However, only a few CDs are considered safe when parenterally administered, and some of these types (HP-β-CD and SBE-β-CD) are already approved to be used in parenteral dosage forms.
Research on methyl, amino-m, quaternary ammonium, acetal and bioesterified β-CD (β-CD-C10) derivaties is also reviewed. The potential in parenteral formuations with α-CD and γ-CD is also discussed. Clinical trials and regulatory issues are also covered.
Laura Ferreira, Joana Campos, Francisco Veiga, Catarina Cardoso, Ana Cláudia Paiva-Santos (2022)
Cyclodextrin-based delivery systems in parenteral formulations: A critical update review.
European Journal of Pharmaceutics and Biopharmaceutics 178, 35-52.