Posted by This study introduces an integrated, green solubilization strategy by combining pressurized hot water (PHW) treatment with β-cyclodextrin (βCD) complexation to enhance the aqueous solubility and formulation performance of curcumin (Cur). Cur was subjected to three solubilization protocols: PHW processing, βCD complexation, and a novel two-step PHW-Cur/βCD method. Comparative evaluation revealed that the PHW-Cur/βCD complex achieved the highest solubility (0.163 mg.mL−1), representing a ~7.4-fold increase in loading capacity and >95% encapsulation efficiency, outperforming both individual techniques.
Radial distribution function analyses showed possible enhanced hydration shells and increased hydrogen bonding in the PHW Cur/βCD system. These findings suggest the potential of this environmentally friendly dual modality strategy for enhancing both the aqueous solubility and loading performance of poorly water soluble compounds, with prospective applications in pharmaceutical delivery systems and functional food formulations.
Maryam Khajenoori, Shohreh Peimanfard, Motahareh Gazmeh, Ali Haghighi Asl (2026) An integrated green strategy for enhanced aqueous solubility and loading of curcumin: Pressurized hot water meets cyclodextrin complexation. Carbohydrate Polymers 125461. https://doi.org/10.1016/j.carbpol.2026.125461.