Posted by Cyclodextrin-based supramolecular polymers (SPCDs) have emerged as promising platforms for cancer therapy via the utilization of cyclodextrin (CD)-mediated host-guest interactions and supramolecular chemistry. The unique molecular structure of CDs enables efficient encapsulation of therapeutic drugs in hydrophobic cavities. These host-guest interactions facilitate the construction of stimulus-responsive delivery platforms, allowing therapeutic cargoes to be released in the presence of endogenous (pH or enzymes) or external stimuli (light or temperature).
Compared to previous studies, this review offers a distinct advantage by systematically categorizing the various construction strategies of SPCDs, such as supramolecular linear polymers (SLPs), supramolecular hyperbranched polymers (SHPs) and supramolecular cross-linked polymers (SCPs), and elucidating the relationships between their structures and properties. Furthermore, it provides comprehensive coverage of SPCD applications in a variety of cancer treatment modalities, including chemotherapy, phototherapy, chemodynamic therapy, immunotherapy, gene therapy, and protein delivery
Liping Zuo, Kuikun Yang (2025) Cyclodextrin-based supramolecular polymers based on host–guest interactions for cancer therapy. Precision Medicine and Engineering 2, 100044. https://doi.org/10.1016/j.preme.2025.100044.