Posted by Reactive oxygen species (ROS) contribute to endothelial dysfunction, platelet activation, and coagulation abnormalities, promoting thrombus formation. Given the growing interest in non-pharmacological approaches to modulate oxidative stress, we examine the potential of various dietary interventions and antioxidant supplementation in reducing oxidative damage and preventing thrombotic events. Key dietary patterns, such as the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and ketogenic diets, as well as antioxidant-rich supplements like curcumin, selenium, and polyphenols, demonstrate promising effects in improving oxidative stress markers, lipid profiles, and inflammatory responses. This review highlights recent advances in the field, drawing from in vitro, ex vivo, and clinical studies, and underscores the importance of integrating dietary strategies into preventive and therapeutic approaches for managing thrombosis and cardiovascular health.
The delivery of antioxidants as dietary supplements is not discusssed in this paper althogh the low solubility and stability are important issues to address. some examples on curcumin drug deliery systems:
Giurranna, E.; Nencini, F.; Bettiol, A.; Borghi, S.; Argento, F.R.; Emmi, G.; Silvestri, E.; Taddei, N.; Fiorillo, C.; Becatti, M. Dietary Antioxidants and Natural Compounds in Preventing Thrombosis and Cardiovascular Disease. Int. J. Mol. Sci. 2024, 25, 11457. https://doi.org/10.3390/ijms252111457
Featured image: https://www.today.com/health/diet-fitness/mediterranean-diet-rcna63362