Curcumin/amphiphilic cyclodextrin nanoassemblies: Theoretical andspectroscopic studies to address their debut in anticancer therapy

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Curcumin and its derivatives have been extensively used as natural adjuvants in different pathologies including cancer, cardiovascular disease, Alzheimer’s disease, etc. Nowadays research is focused on formulations based on Curcu,im to improve pharmacokinetics, bioavailability, overcoming its low water solubility and instability.

In this paper a novel nanoassembly based on non-ionic amphiphilic cyclodextrin Heptakis(2-O-(oligoethylene glycol)-6-hexylthio)-βCD (SC6OH) and Curcumin with high dispersibility in aqueous medium is reported .

Nanoassemblies based on SC6OH/Curcumin were stable in physiological solutions till to 3 days, by releasing in 8 h the entrapped payload. The high dispersibility of these nanoassemblies, their stability together to an efficacious Curcumin release likely are responsible of the similar IC50s values compared to free Curcumin dissolved in DMSO upon treatment on five different tumoral cells, tagging them as very promising nano-adjuvants in anticancer therapy.

Roberto Zagami, Anna Barattucci, Luigi Monsù Scolaro, Maurizio Viale, Giuseppina Raffaini, Paola Maria Bonaccorsi, Antonino Mazzaglia (2023) Curcumin/amphiphilic cyclodextrin nanoassemblies: Theoretical and spectroscopic studies to address their debut in anticancer therapy. Journal of Molecular Liquids 389,

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