Reduction of thyroid radioactive iodine exposure by oral administration of α-CD

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Iodine is the main ingredient of thyroid hormones (triiodothyronine: T3 and thyroxine.T4. Because the thyroid gland produces thyroid hormones, it selectively absorbs iodine ions from the blood. The iodine ions absorbed in the thyroid gland are oxidized and retained within the follicles as thyronine, a precursor of thyroid hormones.

The uptake of radioactive iodine into the thyroid gland in mice administered with radioactive iodine + α-CD solution, and control mice (in which the α-CD solution was replaced with saline) decreased by approximately 40% in the α-CD group than the non-α-CD group after 24 h. The finding that oral uptake of α-CD has an inhibitory effect on the transfer of radioactive iodine to the thyroid gland has potential for application in many fields such as food, pharmaceuticals, nuclear emergency preparedness, and medicine.

The 24-h thyroid single-photon emission computed tomography (SPECT) images of Na123I and α-CD administered mice, and control mice with normal thyroid function (with α-CD solution replaced with saline).

Nishi, K., Hirota, M., Higaki, S. et al. Reduction of thyroid radioactive iodine exposure by oral administration of cyclic oligosaccharides. Sci Rep 13, 6979 (2023).

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