Alpha-CD-containing oral spray to inhibit the SARS-CoV-2 endocytosis
Italian researchers developed an oral spray (Endovir Stop) containing alpha-cyclodextrin (0.2%) and hydroxytyrosol (3.8%) for the improvement of the defenses
Author: mariavikmon
Oxidized CD bisulfite against influenza A virus
Previous reports have demonstrated that compounds based on sulfo derivatives of oligo- and polysaccharides possess high antiviral activity. In this
Cholesterol chelator, HPβCD for renal diseases
There is increasing evidence that accumulation of intracellular lipids in the kidney contributes to the pathogenesis and progression of kidney
Estimation of BCD daily intake by food
Data from the Centers for Disease Control (CDC) National Health and Nutrition ExaminationSurvey (NHANES) (ClinicalTrials.gov Identifier: NCT00005154) are combined in
Treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin
Niemann-Pick Disease Type C (NPC) is a severe neurovisceral disorder that is pathophysiologically characterized by intracellular transport abnormalities leading to
Technological evolution of cyclodextrins in the pharmaceutical field
Tthe evolution of CD-based pharmaceutical technologies was analyzed, using patent data as the technical source, through a text-mining approach based
Hydroxypropyl-β-cyclodextrin causes massive damage to the developing auditory and vestibular system
2-hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator used to treat Niemann-Pick C1 (NPC1) lysosomal storage disease, causes hearing loss in mammals by
Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing
Remdesivir, an investigational broad-spectrum antiviral agent, formulated with sulfobutyl beta-cyclodextrin, has shown in vitro activity against SARSCoV-2. Currently, remdesivir is
Gilead debates WHO results on low effectivity of remdesivir in Covid-19 mortality rate
Pharmafile reports that Gilead’s antiviral therapy remdesivir has emerged as one of the most promising drugs to treat COVID-19 infections,
Improved fittness of mice treated with gamma-cyclodextrin
In this study [1], young C57BL/6 male mice received a control diet (CON) or an experimental diet that was supplemented