Treatment of acute and long Covid, diabetes, miocardial infarction, and Alzheimer disease. The potential  role of a novel   compound, the trasdermal  glutathione  nano CD complex

Oxidative stress (OS) occurs from excessive reactive oxygen species or a deficiency of antioxidants—primarily endogenous glutathione (GSH). There are many illnesses, from acute and post-COVID-19, diabetes, myocardial infarction to Alzheimer’s disease, that are associated with OS. These dissimilar illnesses are, in order, viral infections, metabolic disorders, ischemic events, and neurodegenerative disorders. Evidence is presented that in many illnesses, (1) OS is an early initiator and significant promotor of their progressive pathophysiologic processes, (2) early reduction of OS may prevent later serious and irreversible complications, (3) GSH deficiency is associated with OS, (4) GSH can likely reduce OS and restore adaptive physiology, (5) effective administration of GSH can be accomplished with a novel nano-product, the GSH/cyclodextrin complex. OS is an overlooked pathological process of many illnesses. Significantly, with the GSH/gamma-cyclodextrin complex, therapeutic administration of GSH is now available to reduce OS. Finally, rigorous prospective studies are needed to confirm the efficacy of this therapeutic approach.

Glutathione (GSH) is an important intracellular antioxidant responsible for neutralizing reactive oxygen species (ROS). In a clinical trial, subjects were sprayed four times twice a day for three days topically on the abdomen [2,3]. The findings of this pilot study suggest GSH–cyclodextrin complex formulation can be used topically as a safe alternative mode of GSH delivery in the peripheral blood. 

References

[1] Yutani R, Venketaraman V, Sheren N. Treatment of Acute and Long-COVID, Diabetes, Myocardial Infarction, and Alzheimer’s Disease: The Potential Role of a Novel Nano-Compound-The Transdermal Glutathione-Cyclodextrin Complex. Antioxidants (Basel). 2024 Sep 12;13(9):1106. doi: 10.3390/antiox13091106

[2] https://cyclodextrinnews.com/2023/10/30/cyclodextrin-enabled-transdermal-peptide-delivery-by-cyclodextrin/

[3] Sasaninia, K.; Kelley, M.; Abnousian, A.; Badaoui, A.; Alexander, L.; Sheren, N.; Owens, J.; Rajurkar, S.; Razo-Botello, B.; Chorbajian, A.; et al. Topical Absorption of Glutathione–Cyclodextrin Nanoparticle Complex in Healthy Human Subjects Improves Immune Response against Mycobacterium avium Infection. Antioxidants 2023, 12, 1375. https://doi.org/10.3390/antiox12071375