Posted by Researchers in Mexico compared two food-grade nanosuspension formulations for oral delivery of acetogenins (ACGs), a potent but poorly soluble class of bioactives. Both nanosuspensions initially formed stable nanoparticles smaller than 130 nm. However, under simulated gastrointestinal conditions, the two systems behaved very differently. The PEG-based formulation remained relatively stable through digestion and released ACGs gradually, while the β-cyclodextrin formulation destabilized significantly in the intestinal phase and released the drug much more rapidly. Because of this rapid release, the β-cyclodextrin nanosuspensions showed substantially higher in vitro bioaccessibility and predicted bioavailability, reaching up to ~95% recovery after digestion compared to ~55% for the PEG system. Both formulations appeared safe in mice.
Chemical structure of annonacin, an example for acetogenins. Structurally, acetogenins are a series of C-35/C-37 compounds usually characterized by a long aliphatic chain bearing a terminal methyl-substituted α,β-unsaturated γ-lactone ring, as well as one to three tetrahydrofuran rings. (Wikipedia)
López-Romero, B. A., Gurrola-Díaz, C. M., Vargas-Guerrero, B., Magaña, M. d. L. G., Montalvo-González, E., & Aguilar-Hernández, G. (2026). Nanosuspensions Loaded with Acetogenins: Physical Stability During In Vitro Digestion, Genotoxicity and Cytotoxicity. Foods, 15(5), 937. https://doi.org/10.3390/foods15050937