Posted by Alpha-cyclodextrin (α-CD) is a non-absorbable and soluble fiber that causes weight loss. In this work it was studied whether this is due to an effect on glucagon-like peptide (GLP-1) secretion. In GLUTag cells, α-CD increased GLP-1 secretion up to 170% via adenylyl cyclase, phospholipase C, and L-type calcium channels dependent processes. In rat isolated colon perfusions, luminal α-CD increased GLP-1 secretion with 20%. In lean mice, once daily α-CD versus saline caused weight loss and lowered the peak in glucose after an oral glucose tolerance test (OGTT). In obese mice, α-CD added to high-fat diet caused weight loss similar to the control group (receiving cellulose). However, compared to cellulose, the α-CD group ate less. During an OGTT, no differences were observed in glucose, insulin and GLP-1. Thus, α-CD increases GLP-1 secretion in a dose-dependent manner and could be a safe and easy addition to food products to help reduce body weight.
Mark M. Smits, Liv von Voss, Anna Katarzyna Drzazga, Emily Eufaula Beaman, Annemette Overgaard Brethvad, Jens Juul Holst, Mette Marie Rosenkilde (2024) Alpha-cyclodextrin increases glucagon-like peptide-1 secretion in multiple models and improves metabolic status in mice. Food Chemistry 460,
140759. https://doi.org/10.1016/j.foodchem.2024.140759
Featured image: Fig. 5. Alpha-cyclodextrin reduces food intake in obese mice. Legend: Male C57Bl/6 J mice fed high-fat diet for over a year switched to high-fat diet containing α-CD (20% of food content, n = 11, red lines/bars) or cellulose (20%; n = 11, black lines / grey bars). Panel (a): effect on body weight; Panel (b): change in body weight per study week
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