Curcumin/Hydroxypropyl-beta-Cyclodextrin (HP-β-CD) and Curcumin/Hydroxypropyl-gamma-Cyclodextrin (HP-γ-CD) inclusion complex nanofibrous webs were produced using electrospinning technique for the purpose of orally fast-dissolving antioxidant food supplement. Curcumin was totally preserved without any loss during the electrospinning process. The aqueous solutions of curcumin/HP-β-CD and curcumin/HP-γ-CD were yielded uniform fiber morphology with ~200 nm and ~900 nm average fiber diameter, respectively. Both Curcumin/CD webs were produced in the form of free-standing and flexible character. Curcumin is a natural bioactive compound with poor water-solubility, however, the phase solubility test and dissolution/disintegration tests (water and artificial saliva) revealed that the water-solubility of curcumin was prominently improved by inclusion complexation with CD.
The dissolution behavior of Curcumin powder, Curcumin/HP-β-CD
web and Curcumin/HP-γ-CD webs in distilled water.
The antioxidant effect of curcumin in Curcumin/CD webs was also enhanced due to higher solubility of curcumin by CD inclusion complex. The IC50 value was determined as web concentrations of 501 μg/mL and 81 μg/mL for Curcumin/HP-β-CD and Curcumin/HP-γ-CD webs, respectively.
The results showed that HP-γ-CyD is significantly more effective than HP-β-CyD in order to enhance the solubility and antioxidant property of curcumin in Curcumin/CyD webs.
Asli Celebioglu, Tamer Uyar: Fast-dissolving antioxidant curcumin/cyclodextrin inclusion complex electrospun nanofibrous webs. Food Chemistry 317 (2020) 126397