Previous reports have demonstrated that compounds based on sulfo derivatives of oligo- and polysaccharides possess high antiviral activity. In this study, the ability of a novel sulfonated derivative of β-cyclodextrin (KS-6469) to inhibit the influenza virus A/WSN/33 (H1N1) infection in vitro and in vivo was examined. The antiviral potential of KS-6469 against the influenza virus was evaluated in Madin-Darby Canine Kidney epithelial cells treated with serially diluted KS-6469. We found out that KS-6469 completely inhibited viral reproduction after treatment of the infected cells with the compound for 48 h. Our data show that double intranasal treatment of mice with KS-6469 fully protected the animals from a lethal infection and significantly decreased the viral titers in the lungs of the infected animals. Thus, the novel sulfonated β-cyclodextrin derivative KS-6469 is a promising candidate for the development of antiviral drugs for preventing and treating the influenza infection.
Kostyro, Soldatenko, & Levchuk. (2019). Optimization of the Production Technology of Oxidized Cyclodextrin Bisulfite. Processes, 7(7), 426. doi:10.3390/pr7070426
Goncharova E.P., Kostyro Y.A., Ivanov A.V., Zenkova M.A. A Novel Sulfonated Derivative of β-Cyclodextrin Effectively Inhibits Influenza A Virus Infection in vitro and in vivo // Acta Naturae. – 2019. – Vol. 11. – N. 3. – P. 20-30. doi: 10.32607/20758251-2019-11-3-20-30
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