Estimation of BCD daily intake by food
Data from the Centers for Disease Control (CDC) National Health and Nutrition ExaminationSurvey (NHANES) (ClinicalTrials.gov Identifier: NCT00005154) are combined in
Author: mariavikmon
Treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin
Niemann-Pick Disease Type C (NPC) is a severe neurovisceral disorder that is pathophysiologically characterized by intracellular transport abnormalities leading to
Technological evolution of cyclodextrins in the pharmaceutical field
Tthe evolution of CD-based pharmaceutical technologies was analyzed, using patent data as the technical source, through a text-mining approach based
Hydroxypropyl-β-cyclodextrin causes massive damage to the developing auditory and vestibular system
2-hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator used to treat Niemann-Pick C1 (NPC1) lysosomal storage disease, causes hearing loss in mammals by
Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing
Remdesivir, an investigational broad-spectrum antiviral agent, formulated with sulfobutyl beta-cyclodextrin, has shown in vitro activity against SARSCoV-2. Currently, remdesivir is
Gilead debates WHO results on low effectivity of remdesivir in Covid-19 mortality rate
Pharmafile reports that Gilead’s antiviral therapy remdesivir has emerged as one of the most promising drugs to treat COVID-19 infections,
Improved fittness of mice treated with gamma-cyclodextrin
In this study [1], young C57BL/6 male mice received a control diet (CON) or an experimental diet that was supplemented
Combined therapy (remdesivir, dexamethasone and monoclonal antibodies) for the treatment of President Trump
Science News reported on October 5, 2020 the opinion of Rajesh Gandhi, an infectious diseases physician at Massachusetts General Hospital
An antibody–supermolecule conjugate for cancer chemotherapy
In this study, antibody–supermolecule conjugates, consisting of a tumor-specific antibody and acid-labile polyrotaxane containing methylated b-cyclodextrin (Me-PRX), were designed to
UofA lab uncovers new mechanism of action against SARS-CoV-2 by antiviral drug remdesivir
News Release on 23-Sep-2020 on Eurokalert Researchers at the University of Alberta have discovered a novel, second mechanism of action