Improved fittness of mice treated with gamma-cyclodextrin

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In this study [1], young C57BL/6 male mice received a control diet (CON) or an experimental diet that was supplemented with 12.88% γCD exchanged against corn starch. After 6 weeks of treatment, the voluntary wheel running activity was monitored and the muscle strength of mice was measured by employing Kondziela’s inverted screen test and forelimb grip strength assay. The γCD-treated mice covered a significantly larger distance per night (CON 8.6 km, γCD 12.4 km) and were significantly longer active (CON 340 min, γCD 437 min). Moreover, γCD-treated mice significantly performed better at the inverted screen test indicated by an enhanced Kondziela score (CON 3.10, γCD 4.63). These data suggest that dietary γCD leads to an increased endurance. A slightly anti-glycemic effect of γCD was also found during oral glucose tolerance test.

The reason might be a steady and longer lasting supply of glucose through a slowed polysaccharide digestion rate by α-amylase in γCD supplemented animals. However, the improvement in voluntary wheel running activity and enhanced muscle strength by γCD could also be a result of behavioral change in mice (similar to hydroxypropyl-γCD’s positive effects in Niemann-Pick type C (NPC1) patient derived fibroblasts through restoring cellular homeostasis [2]). Besides, there is evidence that hydroxypropyl-β-CD treatment via subcutaneous injection improved learning and memory deficits in a transgenic mouse model of Alzheimer disease [3]. The extent to which dietary cyclodextrins have an influence on brain function remains open.

The underlying mechanisms by which cyclic dextrins improve endurance are still not fully understood and further studies are needed to elucidate how γCD can provide a blunted postprandial glucose response and
affect endurance.

The results suggest to use γCD as a putative carbohydrate source in sports nutrition and in roborating diets to counteract age-dependent decline in endurance and muscle strength.

[1] Wupper, S. et al. EFFECTS OF DIETARY GAMMA-CYCLODEXTRIN ON VOLUNTARY ACTIVITY AND MUSCLE STRENGTH IN MICE. Journal of Physiology and Pharmacology 2020, 71, 3.

[2] Singhal A, Krystofiak ES, Jerome WG, Song B. 2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1
deficiency by enhancing lysosome-ER association and autophagy. Sci Rep 2020; 10: 8663. doi:10.1038/s41598-020-65627-4


Yao J, Ho D, Calingasan NY, Lin MT, Beal MF. Neuroprotection by cyclodextrin in cell and mouse models
of Alzheimer disease. J Exp Med 2012; 209: 2501-2513. doi: 10.1084/jem.20121239

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