Posted by 3D cyclodextrin-based metal-organic frameworks (CD-MOFs) have emerged as a biocompatible alternative to conventional MOFs, as they are synthesized using safer, nontoxic, or lower-toxicity components, thereby eliminating the need for potentially hazardous metals and organic linkers commonly employed in traditional MOF synthesis. In CD-MOFs, cyclodextrin molecules serve as organic linkers, while metal sources, such as KOH, NaOH, and KCl, provide the necessary metal ions for framework formation. CD-MOFs form body-centered cubic structures by binding to one of the alkali metal cations through coordination of the secondary face hydroxyl groups on the alternate d-glucopyranosyl residues. Beyond the intrinsic advantages of traditional MOFs, CD-MOFs offer additional benefits, particularly in drug delivery applications, where biocompatibility is a crucial factor. These CD-MOFs can be synthesized through various techniques, and multiple strategies can be employed for drug loading. This review comprehensively examines the synthesis of 3D CD-MOFs, their drug loading methodologies, comparative analysis of these methods in terms of advantages and limitations, and the potential of 3D CD-MOFs as drug delivery systems.
Reference:
Edisan Ş, Mutlu-Ağardan NB. Exploring Cyclodextrin-Based MOFs for Drug Delivery: Synthesis, Applications, and Future Perspectives. ACS Omega. 2026 Jan 22;11(4):4940-4956. doi: 10.1021/acsomega.5c10791.
See also:
Cyclodextrin Metal-Organic Frameworks and Their Applications.Roy I, Stoddart JF.Acc Chem Res. 2021 Mar 16;54(6):1440-1453. doi: 10.1021/acs.accounts.0c00695. Epub 2021 Feb 1.PMID: 33523626
Cyclodextrin-based metal-organic framework materials: Classifications, synthesis strategies and applications in variegated delivery systems. Zhao RN, Zhu BW, Xu Y, Yu SF, Wang WJ, Liu DH, Hu JN.Carbohydr Polym. 2023 Nov 1;319:121198. doi: 10.1016/j.carbpol.2023.121198. Epub 2023 Jul 17.PMID: 37567724Review.
Synthesis Techniques and Biomedical Applications of Cyclodextrin Metal-organic Frameworks. Kankva D, Prajapati P, Elossaily GM, Prajapati B.Curr Med Chem. 2025;32(36):8035-8048. doi: 10.2174/0109298673328126241003092124.PMID: 39440783Review.
Cyclodextrin metal-organic frameworks and derivatives: recent developments and applications.Dummert SV, Saini H, Hussain MZ, Yadava K, Jayaramulu K, Casini A, Fischer RA.Chem Soc Rev. 2022 Jun 20;51(12):5175-5213. doi: 10.1039/d1cs00550b.PMID: 35670434Review.
A γ-cyclodextrin-based metal-organic framework (γ-CD-MOF): a review of recent advances for drug delivery application. Hamedi A, Anceschi A, Patrucco A, Hasanzadeh M.J Drug Target. 2022 Apr;30(4):381-393. doi: 10.1080/1061186X.2021.2012683. Epub 2021 Dec 9.PMID: 34847807Review.