Extraction of mycotoxins from aqueous solutions using beta-cyclodextrin bead polymer

In previous studies, the extraction of mycotoxins alternariol, zearalenone, zearalenols, zearalenone-14-glucoside, and zearalenone-14-sulfate from aqueous solutions (including certain beverages) by beta-cyclodextrin bead polymer (BBP) has been demonstrated [1-5]. In a recent investigation, BBP-induced removal was also tested regarding further 12 mycotoxins, including aflatoxin B1, aflatoxin M1, citrinin, dihydrocitrinone, cyclopiazonic acid, deoxynivalenol, ochratoxin A, patulin, sterigmatocystin, zearalanone, α-zearalanol, and β-zearalanol [6]. BBP was a weak binder of deoxynivalenol, aflatoxin M1, and patulin, it was a moderate binder of aflatoxin B1 and cyclopiazonic acid, while BBP proved to be a strong binder of citrinin, dihydrocitrinone, sterigmatocystin, zearalanone, α-zearalanol, and β-zearalanol. The environmental pH (tested between pH 3.0 and pH 7.0) has no strong effect on the mycotoxin binding ability of BBP, except ochratoxin A which was extracted effectively only at pH 3.0. This study underline that BBP may be suitable for mycotoxin removal/extraction e.g. for decontamination and/or for analytical purposes.

References:

[1] Fliszár-Nyúl E, Lemli B, Kunsági-Máté S, Szente L, Poór M (2019) Interactions of mycotoxin alternariol with cyclodextrins and its removal from aqueous solution by beta-cyclodextrin bead polymer. Biomolecules 9:428. https://doi.org/10.3390/biom9090428

[2] Fliszár-Nyúl E, Szabó Á, Szente L, Poór M (2020) Extraction of mycotoxin alternariol from red wine and from tomato juice with betacyclodextrin bead polymer. J Mol Liq 319:114180. https://doi.org/10.1016/j.molliq.2020.114180

[3] PoórM, Faisal Z, Zand A, Bencsik T, Lemli B, Kunsági-Máté S, Szente L (2018) Removal of zearalenone and zearalenols from aqueous solutions using insoluble beta-cyclodextrin bead polymer. Toxins 10:216. https://doi.org/10.3390/toxins10060216

[4] Faisal Z, Fliszár-Nyúl E, Dellafiora L, Galaverna G, Dall’Asta C, Lemli B, Kunsági-Máté S, Szente L, Poór M (2019) Cyclodextrins can entrap zearalenone-14-glucoside: interaction of the masked mycotoxin with cyclodextrins and cyclodextrin bead polymer. Biomolecules 9:354. https://doi.org/10.3390/biom9080354

[5] Faisal Z, Fliszár-Nyúl E, Dellafiora L, Galaverna G, Dall’Asta C, Lemli B, Kunsági-Máté S, Szente L, Poór M (2020) Interaction of zearalenone-14-sulfate with cyclodextrins and the removal of the modified mycotoxin from aqueous solution by beta-cyclodextrin bead polymer. J Mol Liq 310:113236. https://doi.org/10.1016/j.molliq.2020.113236

[6] Mohos V, Faisal Z, Fliszár-Nyúl E, Szente L, Poór M (2021) Testing the extraction of 12 mycotoxins from aqueous solutions by insoluble beta-cyclodextrin bead polymer. Environ. Sci. Pollut. Res. (Published online) https://doi.org/10.1007/s11356-021-15628-1