Bio-soft cyclodextrin materials

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A recent review of prof. Mazzaglia’s group gives an overview on CD-based nanomaterials of biological relevance focusing on CD self-assembly or assembly with other molecules such as components of biological membranes, drugs, proteins. A fine tuning of molecular components leads to established self-assembled systems which can generate, also in the presence of polymers and/or metal nanoparticles, multifaceted nano- or micro-entities with distinctive biological features. Phototherapeutic nanoassemblies based on amphiphilic and/or polycationic CDs, polyrotaxanes, hybrid organic-inorganic nanoparticles modified with CDs and active targeted nanoassemblies are discussed. These systems are classified in Table 1 [1] giving also the section numbers where they are introduced.

A549 cells: human alveolar basal epithelial cells, Acy: acyclovir, Cid: cidofovir, Con A: conconavalin A, CPT: camptothecin, CyA: cyclosporin A, DOXO: doxorubicin, DTX: docetaxel, FA: folic acid, HAS: human serum albumin, HCC cells: hepatocellular carcinoma cells, HCT116 cells: human colon adenocarcinoma cell lines, HeLa cells: cervical cancer cells, HepG2 cells: human liver carcinoma cell line, MB: methylene blue, MCF-7 cells:  breast adenocarcinoma cells, NPC: Niemann Pick type C disease, PSMA: prostate specific membrane antigen, SH-SY5Y cells: human neuroblastoma cells, SiPc: Si(IV) phthalocyanine, Sor: Sorafenib, TPPS: tetra(4-sulfonatophenyl)porphyrin, ZnPc: Zn (II)-phthalocyanine

[1] Zagami, R., Romeo, A., Mazzaglia, A. Bio-soft cyclodextrin nanomaterials.
Rivista del Nuovo Cimento, 42, 407-441 (2019)
DOI 10.1393/ncr/i2019-10163-3

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