Gamma-cyclodextrin as molecular chaperone in protein delivery and stabilization
The interaction of a small, monomeric cytoplasmic protein, Cellular retinoic acid binding protein I (CRABPI), with cyclodextrins (α-, β-, and
Tag: protein stabilization
Cyclodextrin metal–organic framework-based protein biocomposites
Materials are needed to increase the stability and half-life of therapeutic proteins during delivery. These materials should be biocompatible and
New US patent application on ternary CD/small guest molecule/protein interactions
Cyclolab Ltd filed a patent application (US20220282001) on cyclodextrin containing physical mixtures and inclusion complexes that show improved protein stabilizing
Nanofibrous Formulation of Cyclodextrin Stabilized Lipases for Efficient Pancreatin Replacement Therapies
The purpose of enzyme therapies (ERT) is simple: patients who suffer from enzyme deficiency should be treated by administering enzymes
Clinical Application of Cytokines in Cancer Immunotherapy
Cytokines are key components of the immune system and play pivotal roles in anticancer immune response. Cytokines as either therapeutic
The Role of Cyclodextrins against Interface-Induced Denaturation in Pharmaceutical Formulations
Protein-based pharmaceutical products are subject to a variety of environmental stressors, during both production and shelf-life. In order to preserve
Cyclodextrin to formulate proteins – dream or reality
Several cyclodextrins have been claimed by dozens of papers including huge works of Serno [1] and Hartl [2] to be