Alterations in Proteostasis Mechanisms in Niemann–Pick Type C Disease
Niemann–Pick Type C (NPC) represents an autosomal recessive disorder with an incidence rate of 1 in 150,000 live births, classified
Tag: Cholesterol
Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy
Ferroptosis is a regulated cell death process caused by lipid peroxidation of membrane unsaturated fatty acids catalyzed by iron ions
Impact of cholesterol homeostasis within cochlear cells on auditory development and hearing loss
Cholesterol is the most abundant sterol molecule in mammalian cells, which not only constitutes the cell membrane but also plays
Cyclodextrin-Mediated Cholesterol Depletion Induces Adiponectin Secretion in 3T3-L1 Adipocytes
Adipocytes are known to store a significant amount of non-esterified cholesterol in their lipid droplets. It has been hypothesized that
Oral alpha-cyclodextrin reverses cholesterol-crystal-induced retinal pathology in a rodent model of type 2 diabetes (T2D)
Dyslipidemia is common in individuals with T2D and clinical studies show cholesterol and lipid management reduce diabetic retinopathy (DR) progression.
Cyclodextrin-loaded nanobubbles reduce cholesterol and atherosclerosis in vivo
Polymeric nanobubbles were prepared by using polybutlycyanoacrylate. The incorporation of near-infrared dye (IR780) resulted in a multimodal contrast NB, which
HPBCD was tested as a possible therapeutic agent in Amyotrophic Lateral Sclerosis (ALS) model
Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND), is a rare and terminal neurodegenerative disease that results
Comparison of cholesterol complexation with β-cyclodextrin derivatives: A combined theoretical and experimental study
This study [1] aimed to compare differences in interactions between cholesterol and β-cyclodextrin and its derivatives for selecting a suitable
Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products
Novel cyclodextrin derivatives, such as polyrotaxanes, cyclodextrin-polymer conjugates, and thiolated cyclodextrins, are among the most promising candidates in drug delivery.
Complexation of cholesterol with β-cyclodextrin derivatives: A combined theoretical and experimental study
This study aimed to compare differences in interactions between cholesterol and β- cyclodextrin and its derivatives for selecting a suitable