Cyclodextrin-based formulation boosts in vitro anti-tumor potential and lowers toxicity in zebrafish
Paclitaxel (PCTX) is one of the most prevalently used chemotherapeutic agents. However, its use is currently beset with a host
Tag: Cancer therapy
Stabilized, ROS-sensitive β-cyclodextrin-grafted hyaluronic supramolecular nanocontainers for CD44-targeted anticancer drug delivery
Hyaluronic acid (HA)-based tumor microenvironment-responsive nanocontainers are attractive candidates for anticancer drug delivery due to HA’s excellent biocompatibility, biodegradability, and
Codelivery of Doxorubicin and p53 Gene by β-Cyclodextrin-Based Supramolecular Nanoparticles
A supramolecular system was developed for codelivery of doxorubicin (Dox) and p53 gene based on a β-CD-containing star-shaped cationic polymer.
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches
Ferroptosis, a unique form of programmed cell death, is initiated by an excess of iron accumulation and lipid peroxidation-induced damage.
Does Vinblastine Retain its Anticancer Effect in the Presence of Cyclodextrin? A Preliminary Study
In this work, investigating the synthesis and characteristics of cyclodextrin-vinblastine compositions, derivatives of the electroneutral DIMEB and the polyanionic SBECD
Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy
Lipid metabolism in cancer cells has garnered increasing attention in recent decades. Cancer cells thrive in hypoxic conditions, nutrient deficiency,
Regulating Tumor-Associated Macrophage Polarization by Cyclodextrin-Modified PLGA Nanoparticles Loaded with R848 for Treating Colon Cancer
This study aimed to develop a novel and feasible modification strategy to improve the solubility and antitumor activity of resiquimod
Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy
Ferroptosis is a regulated cell death process caused by lipid peroxidation of membrane unsaturated fatty acids catalyzed by iron ions
Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment
Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application
Antinociceptive Effect of a p-Cymene/β-Cyclodextrin Inclusion Complex in a Murine Cancer Pain Model
Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a