Reducing Cholesterol with β-CDP: Insights for NPC and AD
Niemann–Pick disease type C (NPC) and Alzheimer’s disease (AD) are neurodegenerative disorders characterised by cognitive dysfunction and neurological impairment. In
Tag: autophagy
Enhancing the Water Solubility and Efficacy of Anticancer Drugs Using Hydroxypropyl-β-Cyclodextrin
Previous studies have demonstrated that the solubility and biocompatibility of poorly water-soluble anti-cancer agents can be improved by complexation with
A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice
A β-CDP (CycloLab) was used for the experiments. The purity of the β-CDP was >95 %. The β-CDP contained <1 % of
A β-cyclodextrin polymer reduces cholesterol accumulation and mitigates autophagy dysfunction in vitro and in a Niemann–Pick Type C animal model
Niemann–Pick disease type C (NPC) and Alzheimer’s disease (AD) are both characterised by cognitive decline and neurological impairment. In each
Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease
This noticable mini review was published in the last year but worth not to overlook as it is in line
Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks
Aging is a complex and time-dependent decline in physiological function that affects most organisms, leading to increased risk of age-related
Mannose-methyl-β-cyclodextrin suppresses tumor growth by targeting both colon cancer cells and tumor-associated macrophages
Methylated β-cyclodextrin (MβCD) can extract cholesterol from lipid rafts and induce apoptosis in cancer cells by inhibiting activation of the
Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States
Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of
Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment
Parkinson-disease-patient-derived cells presented differences in their energetic profile, imbalanced proliferation, apoptosis, mitophagy, and a reduced differentiation efficiency to tyrosine hydroxylase
Mannose-modified methyl-β-cyclodextrin suppresses tumor growth
Methylated β-cyclodextrin (MeβCD) can extract cholesterol from lipid rafts and induce apoptosis in cancer cells by inhibiting activation of the