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Tag: autophagy

February 19, 2026 CD as API / Drug delivery / Pharma applications

Enhancing the Water Solubility and Efficacy of Anticancer Drugs Using Hydroxypropyl-β-Cyclodextrin

Previous studies have demonstrated that the solubility and biocompatibility of poorly water-soluble anti-cancer agents can be improved by complexation with

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January 27, 2026 CD as API / Pharma applications

A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice

A β-CDP (CycloLab) was used for the experiments. The purity of the β-CDP was >95 %. The β-CDP contained <1 % of

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a rat is standing on top of a plastic container
November 24, 2025 CD as API / CD derivatives / Pharma applications

A β-cyclodextrin polymer reduces cholesterol accumulation and mitigates autophagy dysfunction in vitro and in a Niemann–Pick Type C animal model

Niemann–Pick disease type C (NPC) and Alzheimer’s disease (AD) are both characterised by cognitive decline and neurological impairment. In each

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December 12, 2024 CD as API / Pharma applications

Restoring autophagic function: a case for type 2 diabetes mellitus drug repurposing in Parkinson’s disease

This noticable mini review was published in the last year but worth not to overlook as it is in line

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July 8, 2024 CD as API / Drug delivery / Pharma applications

Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks

Aging is a complex and time-dependent decline in physiological function that affects most organisms, leading to increased risk of age-related

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December 19, 2023 CD as API / CD derivatives / Pharma applications

Mannose-methyl-β-cyclodextrin suppresses tumor growth by targeting both colon cancer cells and tumor-associated macrophages

Methylated β-cyclodextrin (MβCD) can extract cholesterol from lipid rafts and induce apoptosis in cancer cells by inhibiting activation of the

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November 27, 2023 Life sciences

Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States

Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of

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February 21, 2023 CD as API / Pharma applications

Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment

Parkinson-disease-patient-derived cells presented differences in their energetic profile, imbalanced proliferation, apoptosis, mitophagy, and a reduced differentiation efficiency to tyrosine hydroxylase

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February 3, 2023 CD as API / CD derivatives / Pharma applications

Mannose-modified methyl-β-cyclodextrin suppresses tumor growth

Methylated β-cyclodextrin (MeβCD) can extract cholesterol from lipid rafts and induce apoptosis in cancer cells by inhibiting activation of the

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July 28, 2022 Drug delivery / Pharma applications

Cellular Effects of Cyclodextrins: Studies on Caco-2 and HeLa Cells

In this work the cellular internalization and the intracellular effects of (2-hydroxypropyl)-beta (HPBCD) and random methyl-beta cyclodextrin (RAMEB) on Caco-2

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