Cellular Effects of Cyclodextrins: Studies on Caco-2 and HeLa Cells
In this work the cellular internalization and the intracellular effects of (2-hydroxypropyl)-beta (HPBCD) and random methyl-beta cyclodextrin (RAMEB) on Caco-2
Tag: autophagy
Cancer-Related Intracellular Signalling Pathways Activated by Doxorubicin/Cyclodextrin-Graphene-Based Nanomaterials
In the last decade, nanotechnological progress has generated new opportunities to improve the safety and efficacy of conventional anticancer therapies.
HPBCD for Treatment of Parkinson Disease
The recent work of Jarazo et al. demonstrates that HP-β-CD ameliorates the dopaminergic neuronal loss phenotype, confirming the therapeutic potential
Folate-appended CDs in cancer therapy
The team of Motoyama in Kumamoto has recently published new results on folate-appended CDs in leukemia and ovarian cancer (1,2).
Use of cyclodextrins in diseases and disorders involving phospholipid dysregulation
A patent application by Knut M. Wittkowski (ASDERA LLC, US) entitled “Use of cyclodextrins in diseases and disorders involving phospholipid
Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment
OrganoTherapeutics in collaboration with University of Luxemburg has published interestingin vitro and in vivo results on the effects of HPBCD
Press Release – Development of Autophagy Inducing Cyclodextrin Derivatives for Aging-associated Diseases
CycloLab Cyclodextrin R&D Ltd. proudly announces winning of a national grant about the development of cyclodextrin-dervatives for autophagy-associated neurodegenerative diseases.
An antibody–supermolecule conjugate for cancer chemotherapy
In this study, antibody–supermolecule conjugates, consisting of a tumor-specific antibody and acid-labile polyrotaxane containing methylated b-cyclodextrin (Me-PRX), were designed to
Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic Targets.
The plasma membrane microdomain lipid rafts have been found by researchers to be involved in the replication cycle of numerous
Cyclodextrin to prevent abdominal aortic aneurysm
The scientists at University of Michigan Medical Center, Ann Arbor, MI published on a new application of hydroxypropyl beta-cyclodextrin (HPβCD)