Posted by Aging is a complex and time-dependent decline in physiological function that affects most organisms, leading to increased risk of age-related diseases. Investigating the molecular underpinnings of aging is crucial to identify geroprotectors, precisely quantify biological age, and propose healthy longevity approaches. This review explores pathways that are currently being investigated as intervention targets and aging biomarkers spanning molecular, cellular, and systemic dimensions. Interventions that target these hallmarks may ameliorate the aging process, with some progressing to clinical trials. Biomarkers of these hallmarks are used to estimate biological aging and risk of aging-associated disease. Utilizing aging biomarkers, biological aging clocks can be constructed that predict a state of abnormal aging, age-related diseases, and increased mortality.
This review [1] also discusses the difficulties in constructing biological-age clocks (which is different from the chronological age clocks) based on the aging biomarkers.
Although the paper does not aim to explore the potntial effect of cyclodextrins in aging we can easily understand that among the compounds targeting hallmarks of aging there are several ones already studied for improvement of pharmacokinetics by using cyclodextrins. Some examples: quercetin, CoQ10, spermidine, phenothiazines, omega-3 fatty acids, epicatechin, etc.
Alpha-CD itself proved to be an autophagy activator. Given the essential role of the different autophagic branches in the context of aging and age-associated ailments, research efforts are proposing several compound-based strategies, e.g. alpha-CD to activate autophagy .
[1] Yusri, K.; Kumar, S.; Fong, S.; Gruber, J.; Sorrentino, V. Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks. Int. J. Mol. Sci. 2024, 25, 6793. https://doi.org/10.3390/ijms25126793