Antibody conjugated cyclodextrin for tumor drug delivery
Abzena company developed a series of antibody drug conjugates (ADCs) using IgG1, IgG2, IgG4, mAbs, and other antibodies modified with
Category: Pharma applications
New book: Host-Guest Polymer Complexes
A new open-access book on host-guest polymer complexes edited by A E. Tonelli, G. Narayanan and A. Gurarslan was published
Allergic Eye treatment with Cyclodextrins
There is a not extremely recent but certainly very interesting patent application related to a special use of cyclodextrins, namely
A patent application for potential medical use of CD-based (poly)catenanes
Researchers from Kumamoto University (Hidetoshi Arima, Keiichi Motoyama, Taishi Higashi) filed an international patent application on a novel synthesis of
Bitter taste? Masked!
Although there are several commercial examples for the uses of cyclodextrins as taste-masking agents (Nicorette, Ulgut, Zyrtec, etc), their use
A clinical phase1 study of Hydroxypropyl-beta-cyclodextrin (HPBCD)-adjuvanted influenza split vaccine
Osaka University Hospital with the support of Daichii Sankyo is sponsoring a clinical trial on a vaccine against influenza virus.
Cyclodextrins in oral formulations – has the time of supergenerics come?
Development of generic formulations with cyclodextrins for oral delivery has been neglected for several decades, since the CD-enabled formulations often
Therapeutic potential for cyclodextrin‐based macromolecular systems in NPC
A paper has just come out in Macromolecular Rapid Communications highlighting the potential benefits of cyclodextrin-based macromolecular systems as cholesterol-mopping
Bridging cyclodextrin to transfect siRNA
The bridging of beta-cyclodextrin with an ammonium linker which bears a hydrophobic substituent efficiently forms supramolecular polymers, avoiding the competing
Amgen Submits Supplemental New Drug Application For KYPROLIS® (carfilzomib)
Amgen announced on the 27th August, 2018 the submission of a supplemental New Drug Application (sNDA) to the U.S. Food