Nano-Enabled Toxicity of Pharmaceutical Excipients
Nanotechnology has brought revolutionary advances in the pharmaceutical field. Among drug delivery systems, nanocarriers, which enhance the solubility, stability and
Category: Pharma applications
Biphasic dissolving microneedles with cyclodextrin inclusion complexes for enhanced delivery of poorly soluble drugs
Dissolving microneedles (DMNs) have been widely investigated for transdermal drug delivery, yet their clinical translation and commercialization remain limited, primarily
CD-based supramolecular polymers based on host–guest interactions for cancer therapy
Cyclodextrin-based supramolecular polymers (SPCDs) have emerged as promising platforms for cancer therapy via the utilization of cyclodextrin (CD)-mediated host-guest interactions
PEG-β-Cyclodextrin polymer-based formulation to increase the antiangiogenic activity of rutin in vivo
Rutin (RTN) is a natural flavonoid with well-documented anti-angiogenic, antioxidant, anti-inflammatory, and anti-cancer properties. However, its therapeutic potential is limited
Cyclarity Unveils First-Ever Clinical Data Demonstrating Excretion of Oxidized Cholesterol, at American Heart Association Vascular Discovery Scientific Sessions
Cyclarity Therapeutics, Inc., a clinical stage biopharmaceutical company engineering cyclodextrin molecules into simple, scalable, and affordable therapies that bind and
CDs as Modulators of Regulated Cell Death: Implications for Immunometabolism and Therapeutic Innovation
This review critically examines how cyclodextrins modulate regulated cell death pathways and the implications for immunometabolism and therapeutic translation. Increasing
HPBCD against acute and subacute infarcts in a mouse model of ischemic stroke
HPβCD has also been investigated as an active pharmaceutical ingredient (API) for the prospective treatment of ischemic stroke. We previously
Structural diversity of cyclodextrin metal-organic frameworks enables their diverse applications
Cyclodextrin-based metal-organic frameworks (CD-MOFs) constitute a distinctive family of porous solids that combine the modularity of coordination networks with the
Exploring Cyclodextrin-Based MOFs for Drug Delivery: Synthesis, Applications, and Future Perspectives
3D cyclodextrin-based metal-organic frameworks (CD-MOFs) have emerged as a biocompatible alternative to conventional MOFs, as they are synthesized using safer,
Sugammadex analog water soluble BCD polymer for peptide complexes
In this work, an integrated biophysical and biological study is presented describing both the structural and biological features of the