Ozonized HPBCDs as novel materials with oxidative and bactericidal properties
Ozonized (2-Hydroxypropyl)-β-cyclodextrins (Oz-HPbCDs) were produced by direct gas/solid reaction between gaseous ozone (O3) and solid HPbCD. The solid materials obtained
Category: Pharma applications
CD-containing generic drugs in Japan, further examples
In addition to several multivitamin and herbal formulations containing cyclodextrin the following generic drugs were found on kegg.jp//kegg/medicus.html: (see also:
Appropriate Dosing of Sugammadex in Morbidly Obese Patients
A meta-analysis has been recently published about the dosing of sugammadex (SGM) for neuromuscular blockade (NMB) induced muscle relaxation in
HPBCD inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines
COVID-19 is marked by extensive damage to the respiratory system, often accompanied by systemic manifestations, due to both viral cytopathic
Safety, Immunogenicity of a Novel HPBCD-Adjuvanted Influenza Vaccine
A novel quadrivalent seasonal influenza vaccine (FluCyd-vac) adjuvanted with hydroxypropropyl-b-cyclodextrin (HP-β-CD) was found to be safe and immunogenic despite containing
Chewable formulations – recent reviews
Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric
CD-containing generic drugs in Japan, examples
There are a number of CD-containing generic drugs produced in Japan Cetirizine Hydrochloride OD Tablets 5mg/10mg “Sawai” Orally disintegrating tablet.
Dispersome® – a new Bioavailability Enhancing Technology
Poor drug solubility is one of the most challenging issues in drug development. Up to 90 % of all newly
The Effect of Cyclodextrins in Cholesterol and Ganglioside Depletion in Rat Brain Synaptosomes
In this recently published article, the effect of four cyclodextrin derivatives on cholesterol and ganglioside depletion was investigated: two alpha
Cyclodextrin-based delivery systems in parenteral formulations: A critical update review
Amongst all the strategies that can be useful in the development of parenteral formulations, the formation of water-soluble host-guest inclusion