The system formulated from gold nanoparticles (AuNPs) linked with CD molecules combines the advantages of both CD and AuNPs. Cyclodextrins benefit in increasing aqueous drug solubility, loading capacity, stability, and size control of gold NPs. Also, AuNPs are applied as diagnostic and therapeutic agents because of their unique chemical properties. Plus, AuNPs possess several advantages such as ease of detection, targeted and selective drug delivery, greater surface area, high loading efficiency, and higher stability than microparticles. In the present article, the potential pharmaceutical applications of CD-derived AuNPs are demonstreated in biomedical fields including antibacterial, anticancer, gene-drug delivery, and various targeted drug delivery applications. Also, the article highlighted the role of CDs in the preparation and improvement of catalytic enzymes, the formation of self-assembling molecular print boards, the fabrication of supramolecular functionalized electrodes, and biosensors formation.
Abdellatif AAH, Ahmed F, Mohammed AM, Alsharidah M, Al-Subaiyel A, Samman WA, Alhaddad AA, Al-Mijalli SH, Amin MA, Barakat H, Osman SK. Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles. Int J Nanomedicine. 2023 Jun 14;18:3247-3281. doi: 10.2147/IJN.S405964.