After a recent review on applicatipon of CD-based systems in cancer therapy a new review has been published by Kushik’s lab:
In the recent years, the cyclodextrin (CD) complexation has emerged as existing approach to overcome the problem of poor solubility of ant-cancer drugs. CD-based nano-technological approaches are safe, stable and showed well in vivo tolerance and greater payload for encapsulation of hydrophobic drugs for the targeted delivery. They are generally chosen due to their ability to get self-assembled to form liposomes, nanoparticles, micelles and nano-sponges etc. This review paper describes a birds-eye view of the various CD-based nano-technological approaches applied for the delivery of anti-cancer moieties to the desired target such as CD based liposomes, niosomes, niosoponges, micelles, nanoparticles, monoclonal antibody, magnetic nanoparticles, small interfering RNA, nanorods, miscellaneous formulation of anti-cancer drugs containing CD. Moreover, the author also summarizes the various shortcomings of such a system and their way ahead.
Chopra H, Verma R, Kaushik S, Parashar J, Madan K, Bano A, Bhardwaj R, Pandey P, Kumari B, Purohit D, Kumar M, Bhatia S, Rahman MH, Mittal V, Singh I, Kaushik D. Cyclodextrin-Based Arsenal for Anti-Cancer Treatments. Crit Rev Ther Drug Carrier Syst. 2023;40(2):1-41. doi: 10.1615/CritRevTherDrugCarrierSyst.2022038398.