Globally, obesity and its metabolic complications, which are intimately linked to diet, are major public health problems. Cyclodextrins (CDs) can reduce fat bioavailability and affect metabolism by improving intestinal flora as prebiotics. We compared the effects of three CDs on preventing fat accumulation and remodeling gut microbiota in a high-fat diet-fed C57BL/6J mouse model. α-CD maximized energy expenditure by 12.53%, caused the respiratory exchange ratio (RER) value to drop from 0.814 to 0.788, and increased the proportion of fatty acid oxidation for energy supply. β-CD supplementation resulted in a marked 24.53% reduction in weight gain and a decrease in epididymal-fat-relative weight from 3.76% to 2.09%. It also minimized ectopic fat deposition and improved blood lipid parameters. γ-CD maximized the concentration of short-chain fatty acid (SCFAs) in the cecum from 6.29 to 15.31 μmol/g. All three CDs reduced the abundance ratio of Firmicutes and Bacteroidetes to a low-fat diet level, increased the abundance of Lactobacillus and Akkermansia, and reduced the abundance of Allobaculum and Ruminococcus. These findings imply that a combination of multiple CDs may exert superior effects as a potential strategy for obesity prevention.
In this experiment cellulose was replaced by CDs and only the β-CD-supplemented diet suppressed excess weight gain in mice fed a high-fat diet, but cellulose, α-CD, and γ-CD supplementation had little effect on body weight gain. After 9 weeks of feeding, body weight gain in the BCD group was 24.53% lower compared with that of the HFD baseline group (p < 0.05), and this effect did not depend on energy intake.
Zhu, T.; Zhang, B.; Feng, Y.; Li, Z.; Tang, X.; Ban, X.; Kong, H.; Li, C. Beneficial Effects of Three Dietary Cyclodextrins on Preventing Fat Accumulation and Remodeling Gut Microbiota in Mice Fed a High-Fat Diet. Foods 2022, 11, 1118. https://doi.org/10.3390/foods11081118