CycloLab collaborates with Daicel Corporation

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Daicel Corporation, Japan and CycloLab Cyclodextrin R&D Laboratory, Ltd, Hungary have jointly published a white paper on the bitterness masking effect of β-cyclodextrin in the formulation of orally disintegrating tablets (ODTs) using Daicel’s propriatery excipient mixture called Granfiller D.

Model ODT samples comprising β-cyclodextrin complex of mitiglinide calcium and Granfiller D achieved practical bitterness masking, sufficient tablet hardness and rapid disintegration.

Combining bitterness masking by β-cyclodextrin and swelling matrix of Granfiller D, by synergistic input of both company’s profile strength, a model technology for manufacturing a palatable ODTs was provided in a white paper accessible here.

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