CAVACURMIN®: Study Reveals Increased Metabolic Bioavailability of Tetrahydrocurcumin

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A study recently published in the Journal of Functional Foods shows that ingestion of the curcumin-cyclodextrin complex CAVACURMIN® leads to an increased metabolic bioavailability of tetrahydrocurcumin. A large portion of supplemented curcumin is converted into tetrahydrocurcumin in the body. This metabolite is credited with anti-inflammatory and antioxidant properties. CAVACURMIN® is the only formulation on the market that demonstrably boosts the bioavailability of both curcumin and tetrahydrocurcumin.

Curcumin, the active compound in turmeric, is a powerful antioxidant that supports healthy aging and joint health, as has been demonstrated in various studies. As it is not water-soluble, curcumin is not readily absorbed in the human bloodstream. Its bioavailability can be boosted significantly with the aid of gamma-cyclodextrin. A study published in 2018 shows that the curcuminoids of WACKER’s cyclodextrin complex CAVACURMIN® are absorbed around 40 times more efficiently in the body than those of a standard curcumin extract (Purpura et al. 2018).

As part of a randomized double-blind study, it has now been shown that the metabolic bioavailability of tetrahydrocurcumin is also around 40 times higher following ingestion of CAVACURMIN® compared to a standard curcumin extract (Hundshammer et al. 2021).

Tetrahydrocurcumin is a curcumin metabolite credited with additional health-promoting properties. The metabolic bioavailability gives the ratio of the in-vivo production of tetrahydrocurcumin to the absorbed amount of curcumin. Another finding of the long-term study is that, after only four weeks, daily ingestion of CAVACURMIN® (approx. 340 milligrams curcumin each time) leads to a consistently high blood concentration of curcumin and tetrahydrocurcumin. This effect can be measured after 12 weeks as well. The long-term study furthermore confirmed very high tolerability of CAVACURMIN®.

CAVACURMIN® can be easily processed in food supplements, such as tablets, capsules and energy bars or functional beverages.

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