Coronavirus 2 is a member of a virus family with lipid envelope that fuses with host cell through endocytosis, internalizing its components in the cell. In vitro cell models have shown that depletion of cholesterol by cyclodextrin, and particularly methyl beta cyclodextrin disturb the host cell membrane lipid composition this way reducing the attachment of the virus to the protein receptors. This review aims to summarize the state of the art of research concerning the use of cyclodextrin or its complexes as a potential treatment against this new virus and update work already published.
Sofiane F, Lamia T, Mohamed S, Mokrane IO. The Use of cyclodextrin or its complexes as a potential treatment against the 2019 novel coronavirus. A mini-review [published online ahead of print, 2020 Sep 17]. Curr Drug Deliv. 2020;10.2174/1567201817666200917124241. doi:10.2174/1567201817666200917124241