Large ring cyclodextrins in 100 mg scale

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In a recent paper of Zimmermann’s group, purification of large ring cyclodextrins was reported [1]. Reversed phase chromatography allowed to prepare CD10, CD11 and CD12 in ever largest quantity (140-155 mg each) in high purity (91-95%). This high amount of material allowed first toxicity tests. None of the three CDs showed any toxic effects on HEK 293 and MCF-7 human cell lines as expected.

The potential application of these CDs as chiral selector in capillary electrophoresis was also studied. Three racemic compounds which were not separable by the “normal-size” CDs (CD6, CD7 and CD8) were enantioseparated with acceptable resolution (Rs>1.5): Mefloquine with CD10, Carvedilol with CD11 and Primaquine both with CD10 and CD11.

The featured image is from Gotsev et al [2]


  1. Sonnendecker C, Thürmann S, Przybylski C, Zitzmann FD, Heinke N, Krauke Y, Monks K, Robitzki AA, Belder D, Zimmermann W (2019) Large‐Ring Cyclodextrins as Chiral Selectors for Enantiomeric Pharmaceuticals. Angewandte Chemie 58, 6411–6414
  2. Gotsev MG, Ivanov PM, Jaime C. (2007) Molecular dynamics study of the conformational dynamics and energetics of some large-ring cyclodextrins (CDn, n = 24, 25, 26, 27, 28, 29). Chirality. 19(3):203-13.

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