Cannabis has been used for medicinal purposes for thousands of years. Its active compounds produce pharmacological effects throughout the body, especially in the central nervous system and the immune system. Recent global changes in the regulations of handling THC and CBD are drawing a lot of attention to developing both nutraceutical and pharma formulations. Since these compounds are technically insoluble in water, cyclodextrins are quite a trivial choice, even 1000-fold solubility increases has been reported along with increase in oral and sublingual bioavailability, corneal penetration and other advantages. Learn more in CD News!
With Epidiolex earning FDA’s blessing and moving cannabidiol into the medical mainstream a new era starts for cyclodextrins-based cannabinoids not only as nutraceuticals but also as pharmcaceutics. The high affinity of the cyclodextrin cavity towards the cannabinoid structure holds a great promise to develop different liquid formulations.