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Tag: solubility

May 29, 2025 Drug delivery / Pharma applications

Theoretical Calculation of the Solubility and Other Parameters for Poorly Water-Soluble Compounds from Binding Constants of Inclusion Complexes

Experimental determination of solubility is a time-consuming procedure with relatively high reagent consumption. The solubility of poorly water-soluble compounds in

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May 16, 2025 Drug delivery / Pharma applications / Uncategorized

SBECD, HPBCD and hydrophilic polymers to enhance the solubility of Benzthiazide, Isoxicam, and Piroxicam

The bioavailability of a drug depends, among other parameters, on solubility. One of the strategies used to enhance the solubility

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March 23, 2023 E-ducation

Anomalous Properties of Cyclodextrins and Their Complexes in Aqueous Solutions

Since their discovery, CDs have been the subject of close to 100,000 publications, including about 61,000 peer-reviewed scientific articles and

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January 5, 2023 Drug delivery / Pharma applications

Inclusion complexes of the steroid hormones 17β-estradiol and progesterone with β- and γ-cyclodextrin hosts

This study addresses the poor solubility of two potent steroid hormones, 17β-estradiol (BES) and progesterone (PRO), via their complexation with

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July 20, 2022 Drug delivery / Pharma applications

Melatonin/Cyclodextrin Inclusion Complexes: A Review

Melatonin (MLT) is involved in many functions of the human body, mainly in sleeping-related disorders. It also has anti-oxidant potential

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April 27, 2022 Analysis

Cyclodextrins interfere in the ORAC method to measure antioxidant activity

                Oxygen Radical Absorbance Capacity (ORAC) is a water-based method commonly used to determine the antioxidant capacity of bioactive compounds

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December 20, 2021 Drug delivery / Pharma applications

Pilocarpine eye drops (Vuity)

VUITY™ may help elderly people to read without their reading glasses [1] Elderly people can soon read without the help

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March 3, 2021 Drug delivery / Pharma applications

Improving Bioavailability & Solubility

Drug Development & delivery published on the virtual 2020 Global Drug Bioavailability Enhancement Summit, which this past December showcased novel

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October 30, 2020 Pharma applications

Technological evolution of cyclodextrins in the pharmaceutical field

Tthe evolution of CD-based pharmaceutical technologies was analyzed, using patent data as the technical source, through a text-mining approach based

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October 7, 2020 Drug delivery / Pharma applications

Inclusion complex of chrysin with sulfobutyl ether-β-cyclodextrin

The work of Kulkarni and Belgamvar [1] demonstrates the impact of sulfobutyl ether-β-cyclodextrin (SBE-β-CD) complexation on the solubility, dissolution and

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