Since their discovery, CDs have been the subject of close to 100,000 publications, including about 61,000 peer-reviewed scientific articles and about 32,000 patents, most of which have been published during the past few decades (SciFinder; American Chemical Society, February 2023). Hence, scientific and industrial interest in CDs is significant and rapidly growing. Nevertheless, CDs are still surprising investigators with their unexpecting and, sometimes, hard-to-explain properties.
The paper of Loftsson et al. is especially useful for those who are beginner in the cyclodextrin application. It explains the anomalous solubility of CDs and complexes emphasizing their aggregation often overlooked, why aqueous CD solutions can be considered as aqueous solutions containing organic cosolvents.
Loftsson, T.; Sigurdsson, H.H.; Jansook, P. Anomalous Properties of Cyclodextrins and Their Complexes in Aqueous Solutions. Materials 2023, 16, 2223. https://doi.org/10.3390/ma16062223