Nano-Enabled Toxicity of Pharmaceutical Excipients
Nanotechnology has brought revolutionary advances in the pharmaceutical field. Among drug delivery systems, nanocarriers, which enhance the solubility, stability and
Tag: ototoxicity
The mechanism of ototoxicity studied by using HPBCD
The cochlea is the sensory organ responsible for hearing. Central to its sensory functions is the organ of Corti, a
Novel insights from a quantitative analysis of cyclodextrin-induced ototoxicity in mice
The cochlea is vulnerable to various pathological conditions, with sensory cells typically being the primary targets of damage. However, supporting
Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
Cyclodextrins (CDs), the therapeutic candidates for Niemann–Pick disease type C (NPC), function dually as a shuttle and sink that catalytically
Why HPGCD is better for NPC treatment compared to HPBCD?
Niemann-Pick disease type C (NPC) is a lysosomal storage disorder with disrupted intracellular cholesterol trafficking. HP-β-CD is a cholesterol solubilizer
Ototoxicity of cyclodextrin derivatives
There are two possible mechanisms behind the ototoxicity of 2-hydroxypropyl-β-cyclodextrin (HPBCD) treatment. One is : the possible interaction of HPBCD
Cyclodextrin polymer of reduced ototoxicity improves atherosclerosis therapy
Although CD has been engineered into various nano-sized formulations, their main role was to incorporate a drug of interest for